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5lxf
From Proteopedia
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==Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant== | ==Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant== | ||
| - | <StructureSection load='5lxf' size='340' side='right' caption='[[5lxf]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='5lxf' size='340' side='right'caption='[[5lxf]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5lxf]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5lxf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LXF FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxf OCA], [https://pdbe.org/5lxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lxf RCSB], [https://www.ebi.ac.uk/pdbsum/5lxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN] Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> <ref>PMID:20829061</ref> <ref>PMID:20504948</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5lxf" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5lxf" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]] | ||
| + | *[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Bakhman | + | [[Category: Large Structures]] |
| - | [[Category: Kosloff | + | [[Category: Bakhman A]] |
| - | [[Category: Levaot | + | [[Category: Kosloff M]] |
| - | [[Category: Papo | + | [[Category: Levaot N]] |
| - | [[Category: Rosenfeld | + | [[Category: Papo N]] |
| - | [[Category: Shahar | + | [[Category: Rosenfeld L]] |
| - | [[Category: Zarivach | + | [[Category: Shahar A]] |
| - | [[Category: Zur | + | [[Category: Zarivach R]] |
| - | + | [[Category: Zur Y]] | |
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Current revision
Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant
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Categories: Homo sapiens | Large Structures | Bakhman A | Kosloff M | Levaot N | Papo N | Rosenfeld L | Shahar A | Zarivach R | Zur Y
