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5ojk

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Current revision (16:52, 13 December 2023) (edit) (undo)
 
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==Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B))==
==Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B))==
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<StructureSection load='5ojk' size='340' side='right' caption='[[5ojk]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='5ojk' size='340' side='right'caption='[[5ojk]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ojk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OJK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ojk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OJK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NLGN1, KIAA1070 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ojk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojk OCA], [http://pdbe.org/5ojk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ojk RCSB], [http://www.ebi.ac.uk/pdbsum/5ojk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ojk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojk OCA], [https://pdbe.org/5ojk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ojk RCSB], [https://www.ebi.ac.uk/pdbsum/5ojk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NLGN1_HUMAN NLGN1_HUMAN]] Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.[UniProtKB:Q99K10]
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[https://www.uniprot.org/uniprot/NLGN1_HUMAN NLGN1_HUMAN] Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.[UniProtKB:Q99K10]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ojk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ojk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neuroligin|Neuroligin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Aricescu, A R]]
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[[Category: Large Structures]]
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[[Category: Elegheert, J]]
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[[Category: Aricescu AR]]
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[[Category: Cell adhesion]]
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[[Category: Elegheert J]]
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[[Category: Neuroligin-neurexin]]
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[[Category: Spliced sequence b]]
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[[Category: Synaptic organizer protein]]
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Current revision

Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B))

PDB ID 5ojk

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