1mr5
From Proteopedia
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==Orthorhombic form of Trypanosoma cruzi trans-sialidase== | ==Orthorhombic form of Trypanosoma cruzi trans-sialidase== | ||
| - | <StructureSection load='1mr5' size='340' side='right' caption='[[1mr5]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='1mr5' size='340' side='right'caption='[[1mr5]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1mr5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1mr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MR5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr5 OCA], [https://pdbe.org/1mr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mr5 RCSB], [https://www.ebi.ac.uk/pdbsum/1mr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mr5 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q26966_TRYCR Q26966_TRYCR] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mr5 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mr5 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Trans-sialidases (TS) are GPI-anchored surface enzymes expressed in specific developmental stages of trypanosome parasites like Trypanosoma cruzi, the etiologic agent of Chagas disease, and T. brucei, the causative agent of sleeping sickness. TS catalyzes the transfer of sialic acid residues from host to parasite glycoconjugates through a transglycosidase reaction that appears to be critical for T. cruzi survival and cell invasion capability. We report here the structure of the T. cruzi trans-sialidase, alone and in complex with sugar ligands. Sialic acid binding is shown to trigger a conformational switch that modulates the affinity for the acceptor substrate and concomitantly creates the conditions for efficient transglycosylation. The structure provides a framework for the structure-based design of novel inhibitors with potential therapeutic applications. | ||
| - | + | ==See Also== | |
| - | + | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Trypanosoma cruzi]] |
| - | [[Category: Alzari | + | [[Category: Alzari PM]] |
| - | [[Category: Amaya | + | [[Category: Amaya MF]] |
| - | [[Category: Buschiazzo | + | [[Category: Buschiazzo A]] |
| - | [[Category: Cremona | + | [[Category: Cremona ML]] |
| - | [[Category: Frasch | + | [[Category: Frasch AC]] |
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Current revision
Orthorhombic form of Trypanosoma cruzi trans-sialidase
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