2e5x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:35, 25 October 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2e5x.gif|left|200px]]
 
-
{{Structure
+
==Structure of nucleotide triphosphate pyrophosphatase from pyrococcus horikoshii OT3==
-
|PDB= 2e5x |SIZE=350|CAPTION= <scene name='initialview01'>2e5x</scene>, resolution 2.00&Aring;
+
<StructureSection load='2e5x' size='340' side='right'caption='[[2e5x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ITT:INOSINE+5&#39;-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+
<table><tr><td colspan='2'>[[2e5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5X FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5x OCA], [https://pdbe.org/2e5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5x RCSB], [https://www.ebi.ac.uk/pdbsum/2e5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5x ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5x TOPSAN]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5x OCA], [http://www.ebi.ac.uk/pdbsum/2e5x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2e5x RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/IXTPA_PYRHO IXTPA_PYRHO] Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.[HAMAP-Rule:MF_01405]<ref>PMID:18062990</ref>
-
 
+
== Evolutionary Conservation ==
-
'''Structure of nucleotide triphosphate pyrophosphatase from pyrococcus horikoshii OT3'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5x_consurf.spt"</scriptWhenChecked>
-
2E5X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5X OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Nucleoside-triphosphate diphosphatase]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Pyrococcus horikoshii]]
+
</jmolCheckbox>
-
[[Category: Single protein]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5x ConSurf].
-
[[Category: Kunishima, N.]]
+
<div style="clear:both"></div>
-
[[Category: Lokanath, N K.]]
+
== References ==
-
[[Category: Mizutani, H.]]
+
<references/>
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
__TOC__
-
[[Category: national project on protein structural and functional analyse]]
+
</StructureSection>
-
[[Category: nppsfa]]
+
[[Category: Large Structures]]
-
[[Category: riken structural genomics/proteomics initiative]]
+
[[Category: Pyrococcus horikoshii OT3]]
-
[[Category: rsgi]]
+
[[Category: Kunishima N]]
-
[[Category: structural genomic]]
+
[[Category: Lokanath NK]]
-
 
+
[[Category: Mizutani H]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:44:12 2008''
+

Current revision

Structure of nucleotide triphosphate pyrophosphatase from pyrococcus horikoshii OT3

PDB ID 2e5x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2e5x"
Personal tools