1lmi

<StructureSection load='1lmi' size='340' side='right' caption='[[1lmi]], [[Resolution|resolution]] 1.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[1lmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LMI FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv1926c, MPT63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmi OCA], [http://pdbe.org/1lmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lmi RCSB], [http://www.ebi.ac.uk/pdbsum/1lmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmi ProSAT], [http://www.topsan.org/Proteins/TBSGC/1lmi TOPSAN]</span></td></tr>

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== Publication Abstract from PubMed ==

MPT63 is a small, major secreted protein of unknown function from Mycobacterium tuberculosis that has been shown to have immunogenic properties and has been implicated in virulence. A BLAST search identified that MPT63 has homologs only in other mycobacteria, and is therefore mycobacteria specific. As MPT63 is a secreted protein, mycobacteria specific, and implicated in virulence, MPT63 is an attractive drug target against the deadliest infectious disease, tuberculosis (TB). As part of the TB Structural Genomics Consortium, the X-ray crystal structure of MPT63 was determined to 1.5-Angstrom resolution with the hope of yielding functional information about MPT63. The structure of MPT63 is an antiparallel beta-sandwich immunoglobulin-like fold, with the unusual feature of the first beta-strand of the protein forming a parallel addition to the small antiparallel beta-sheet. MPT63 has weak structural similarity to many proteins with immunoglobulin folds, in particular, Homo sapiens beta2-adaptin, bovine arrestin, and Yersinia pseudotuberculosis invasin. Although the structure of MPT63 gives no conclusive evidence to its function, structural similarity suggests that MPT63 could be involved in cell-host interactions to facilitate endocytosis/phagocytosis.

Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution.,Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D Protein Sci. 2002 Dec;11(12):2887-93. PMID:12441386<ref>PMID:12441386</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1lmi" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Apostol, M]]

[[Category: Cascio, D]]

[[Category: Eisenberg, D]]

[[Category: Gennaro, M L]]

[[Category: Goulding, C W]]

[[Category: Parseghian, A]]

[[Category: Sawaya, M R]]

[[Category: Structural genomic]]

[[Category: Beta-sandwich]]

[[Category: Immune system]]

[[Category: Tbsgc]]