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(Difference between revisions)

Current revision

HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE

1 Human C-Reactive protein
- 1.1 Function
- 1.2 Structure
2 Phosphocholine
- 2.1 Function
- 2.2 Properties

Human C-Reactive protein

The C-reactive protein is highlighted

Function

Human C-reactive protein is a member of the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli."^[1]

Structure

CRP consists of five identical, noncovalently associated ∼23-kDa protomers arranged symmetrically around a central pore. The term “pentraxins” has been used to describe the family of related proteins with this structure. Each protomer has been found by x-ray crystallography to be folded into two antiparallel β sheets with a flattened jellyroll topology. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. ^[2]

One of the protomers of pentaxin

Phosphocholine

Phosphocholine serves a binding target for C-reactive protein. Phosphocholines are highlighted

Function

General Function: Low-density lipoprotein particle receptor binding

Specific Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.^[3]

Properties

Molecular Weight: 184.152 g/mol

Biofluid Locations: blood, breast milk, cerebrospinal fluid, saliva, urine

Tissue Locations: Brain, Epidermis, Fibroblasts, Intestine, Kidney, Liver, Placenta, Platelet, Stratum Corneum

Cellular location: cytoplasm, exosomes

Target: CRP ^[4]

References

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-{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
+==HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE==
-==Your Heading Here (maybe something like 'Structure')==
+<StructureSection load='1b09' size='340' side='right' caption='Caption for this structure' scene=''>
-<StructureSection load='1bna' size='340' side='right' caption='Caption for this structure' scene=''>
-This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
-== Function ==
+==Human C-Reactive protein==
+The C-reactive protein is highlighted <scene name='77/777631/C-reactive_protein/1'>here.</scene>
+===Function===
+Human C-reactive protein is a member of the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli."<ref>https://www.ncbi.nlm.nih.gov/gene/1401</ref>
-== Disease ==
+===Structure===
+CRP consists of five identical, noncovalently associated ∼23-kDa protomers arranged symmetrically around a central pore. The term “pentraxins” has been used to describe the family of related proteins with this structure. Each protomer has been found by x-ray crystallography to be folded into two antiparallel β sheets with a flattened jellyroll topology. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. <ref> http://www.jbc.org/content/279/47/48487.full</ref>
-== Relevance ==
+One of the protomers of pentaxin <scene name='77/777631/One_protomer/1'>here.</scene>
-== Structural highlights ==
+==Phosphocholine==
+Phosphocholine serves a binding target for C-reactive protein. Phosphocholines are highlighted <scene name='77/777631/Phosphocholine/3'>here.</scene>
+===Function===
+General Function: Low-density lipoprotein particle receptor binding
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+Specific Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.<ref>https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine</ref>
+===Properties===
+Molecular Weight: 184.152 g/mol
+Biofluid Locations: blood, breast milk, cerebrospinal fluid, saliva, urine
+Tissue Locations: Brain, Epidermis, Fibroblasts, Intestine, Kidney, Liver, Placenta, Platelet, Stratum Corneum
+Cellular location: cytoplasm, exosomes
+Target: CRP <ref> https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine </ref>
 </StructureSection>
 == References ==
 <references/>

Sandbox Reserved 1311

From Proteopedia

Current revision

HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE

Contents

Human C-Reactive protein

Function

Structure

Phosphocholine

Function

Properties

References

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