2eal

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[[Image:2eal.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human galectin-9 N-terminal CRD in complex with Forssman pentasaccharide==
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|PDB= 2eal |SIZE=350|CAPTION= <scene name='initialview01'>2eal</scene>, resolution 1.85&Aring;
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<StructureSection load='2eal' size='340' side='right'caption='[[2eal]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>
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<table><tr><td colspan='2'>[[2eal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EAL FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eal OCA], [https://pdbe.org/2eal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eal RCSB], [https://www.ebi.ac.uk/pdbsum/2eal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eal ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2eag|2EAG]], [[2eah|2EAH]], [[2eai|2EAI]], [[2eaj|2EAJ]], [[2eak|2EAK]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eal OCA], [http://www.ebi.ac.uk/pdbsum/2eal PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eal RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2eal_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eal ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human galectin-9 N-terminal CRD in complex with Forssman pentasaccharide'''
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2EAL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAL OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hirabayashi, J.]]
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[[Category: Hirabayashi J]]
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[[Category: Kato, R.]]
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[[Category: Kato R]]
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[[Category: Nagae, M.]]
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[[Category: Nagae M]]
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[[Category: Nakamura, T.]]
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[[Category: Nakamura T]]
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[[Category: Nakamura-Tsuruta, S.]]
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[[Category: Nakamura-Tsuruta S]]
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[[Category: Nishi, N.]]
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[[Category: Nishi N]]
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[[Category: Wakatsuki, S.]]
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[[Category: Wakatsuki S]]
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[[Category: beta sandwich]]
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[[Category: carbohydrate binding protein]]
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[[Category: galectin]]
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[[Category: sugar binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:46:14 2008''
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Current revision

Crystal structure of human galectin-9 N-terminal CRD in complex with Forssman pentasaccharide

PDB ID 2eal

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