6cbx

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(New page: '''Unreleased structure''' The entry 6cbx is ON HOLD Authors: ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra...)
Current revision (14:27, 13 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6cbx is ON HOLD
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==Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497==
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<StructureSection load='6cbx' size='340' side='right'caption='[[6cbx]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6cbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CBX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EW1:[3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl+)-1H-pyrrol-3-yl]methanone'>EW1</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbx OCA], [https://pdbe.org/6cbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cbx RCSB], [https://www.ebi.ac.uk/pdbsum/6cbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
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Authors: ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Hutchinson, A]]
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__TOC__
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[[Category: Arrowsmith, C.H]]
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</StructureSection>
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[[Category: Seitova, A]]
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[[Category: Homo sapiens]]
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[[Category: Dong, A]]
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[[Category: Large Structures]]
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[[Category: Brown, P.J]]
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[[Category: Arrowsmith CH]]
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[[Category: Casimiro-Garcia, A]]
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[[Category: BROWN PJ]]
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[[Category: Zeng, H]]
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[[Category: Bountra C]]
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[[Category: Taylor, A]]
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[[Category: Casimiro-Garcia A]]
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[[Category: Tatlock, J]]
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[[Category: DONG A]]
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[[Category: Owen, A]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A.M]]
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[[Category: Hutchinson A]]
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[[Category: Kumpf, R]]
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[[Category: KUMPF R]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: OWEN A]]
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[[Category: Wu, H]]
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[[Category: Seitova A]]
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[[Category: Bountra, C]]
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[[Category: TATLOCK J]]
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[[Category: TAYLOR A]]
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[[Category: WU H]]
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[[Category: ZENG H]]

Current revision

Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497

PDB ID 6cbx

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