6c1v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:25, 13 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==MBD2 in complex with double-stranded DNA==
==MBD2 in complex with double-stranded DNA==
-
<StructureSection load='6c1v' size='340' side='right' caption='[[6c1v]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='6c1v' size='340' side='right'caption='[[6c1v]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6c1v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C1V FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6c1v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C1V FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c1v OCA], [http://pdbe.org/6c1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c1v RCSB], [http://www.ebi.ac.uk/pdbsum/6c1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c1v ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c1v OCA], [https://pdbe.org/6c1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c1v RCSB], [https://www.ebi.ac.uk/pdbsum/6c1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c1v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN]] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
+
[https://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
 +
 
 +
==See Also==
 +
*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Arrowsmith, C H]]
+
[[Category: Homo sapiens]]
-
[[Category: Bountra, C]]
+
[[Category: Large Structures]]
-
[[Category: Edwards, A M]]
+
[[Category: Synthetic construct]]
-
[[Category: Lei, M]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Min, J]]
+
[[Category: Bountra C]]
-
[[Category: Structural genomic]]
+
[[Category: Edwards AM]]
-
[[Category: Tempel, W]]
+
[[Category: Lei M]]
-
[[Category: Dna binding protein-dna complex]]
+
[[Category: Min J]]
-
[[Category: Dna-binding]]
+
[[Category: Tempel W]]
-
[[Category: Mbd]]
+
-
[[Category: Sgc]]
+

Current revision

MBD2 in complex with double-stranded DNA

PDB ID 6c1v

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6c1v"
Personal tools