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2wks

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==Structure of Helicobacter pylori Type II Dehydroquinase with a new carbasugar-thiophene inhibitor.==
==Structure of Helicobacter pylori Type II Dehydroquinase with a new carbasugar-thiophene inhibitor.==
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<StructureSection load='2wks' size='340' side='right' caption='[[2wks]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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<StructureSection load='2wks' size='340' side='right'caption='[[2wks]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c57|2c57]], [[2c4v|2c4v]], [[1j2y|1j2y]], [[2c4w|2c4w]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [https://pdbe.org/2wks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [https://www.ebi.ac.uk/pdbsum/2wks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wks ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://pdbe.org/2wks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wks ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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[https://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2wks" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2wks" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-dehydroquinate dehydratase]]
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[[Category: Helicobacter pylori]]
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[[Category: Atcc 43504]]
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[[Category: Large Structures]]
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[[Category: Castedo, L]]
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[[Category: Castedo L]]
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[[Category: Gonzalez-Bello, C]]
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[[Category: Gonzalez-Bello C]]
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[[Category: Guardado-Calvo, P]]
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[[Category: Guardado-Calvo P]]
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[[Category: Hawkins, A R]]
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[[Category: Hawkins AR]]
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[[Category: Lamb, H]]
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[[Category: Lamb H]]
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[[Category: Llamas-Saiz, A L]]
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[[Category: Llamas-Saiz AL]]
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[[Category: Otero, J M]]
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[[Category: Otero JM]]
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[[Category: Prazeres, V F.V]]
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[[Category: Prazeres VFV]]
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[[Category: Raaij, M J.van]]
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[[Category: Tizon L]]
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[[Category: Tizon, L]]
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[[Category: Van Raaij MJ]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Lyase]]
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[[Category: Shikimic acid pathway]]
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Current revision

Structure of Helicobacter pylori Type II Dehydroquinase with a new carbasugar-thiophene inhibitor.

PDB ID 2wks

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