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4o9r

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==Human Smoothened Receptor structure in complex with cyclopamine==
==Human Smoothened Receptor structure in complex with cyclopamine==
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<StructureSection load='4o9r' size='340' side='right' caption='[[4o9r]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='4o9r' size='340' side='right'caption='[[4o9r]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o9r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CY8:CYCLOPAMINE'>CY8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.204&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9r OCA], [http://pdbe.org/4o9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o9r RCSB], [http://www.ebi.ac.uk/pdbsum/4o9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9r ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CY8:CYCLOPAMINE'>CY8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9r OCA], [https://pdbe.org/4o9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9r RCSB], [https://www.ebi.ac.uk/pdbsum/4o9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
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[https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Barty, A]]
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[[Category: Homo sapiens]]
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[[Category: Basu, S]]
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[[Category: Large Structures]]
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[[Category: Beyerlein, K R]]
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[[Category: Barty A]]
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[[Category: Boutet, S]]
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[[Category: Basu S]]
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[[Category: Caffrey, M]]
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[[Category: Beyerlein KR]]
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[[Category: Chapman, H N]]
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[[Category: Boutet S]]
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[[Category: Cherezov, V]]
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[[Category: Caffrey M]]
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[[Category: Doak, R B]]
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[[Category: Chapman HN]]
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[[Category: Fromme, P]]
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[[Category: Cherezov V]]
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[[Category: Fromme, R]]
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[[Category: Doak RB]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Fromme P]]
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[[Category: Gati, C]]
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[[Category: Fromme R]]
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[[Category: Grotjohann, I]]
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[[Category: Gati C]]
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[[Category: Han, G W]]
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[[Category: Grotjohann I]]
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[[Category: Howe, N]]
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[[Category: Han GW]]
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[[Category: James, D]]
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[[Category: Howe N]]
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[[Category: Katritch, V]]
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[[Category: James D]]
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[[Category: Kirian, R A]]
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[[Category: Katritch V]]
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[[Category: Klinker, M]]
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[[Category: Kirian RA]]
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[[Category: Koglin, J E]]
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[[Category: Klinker M]]
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[[Category: Kupitz, C]]
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[[Category: Koglin JE]]
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[[Category: Li, D]]
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[[Category: Kupitz C]]
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[[Category: Liu, H]]
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[[Category: Li D]]
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[[Category: Liu, W]]
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[[Category: Liu H]]
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[[Category: Messerschmidt, M]]
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[[Category: Liu W]]
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[[Category: Nelson, G]]
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[[Category: Messerschmidt M]]
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[[Category: Seibert, M M]]
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[[Category: Nelson G]]
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[[Category: Shah, S T.A]]
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[[Category: Seibert MM]]
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[[Category: Shoeman, R L]]
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[[Category: Shah STA]]
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[[Category: Spence, J C.H]]
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[[Category: Shoeman RL]]
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[[Category: Stevens, R C]]
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[[Category: Spence JCH]]
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[[Category: Wacker, D]]
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[[Category: Stevens RC]]
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[[Category: Wang, C]]
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[[Category: Wacker D]]
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[[Category: Wang, D]]
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[[Category: Wang C]]
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[[Category: Weierstall, U]]
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[[Category: Wang D]]
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[[Category: White, T A]]
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[[Category: Weierstall U]]
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[[Category: Willams, G J]]
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[[Category: White TA]]
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[[Category: Zatsepin, N A]]
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[[Category: Willams GJ]]
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[[Category: Cyclopamine]]
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[[Category: Zatsepin NA]]
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[[Category: Free electron laser]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Human smo receptor]]
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[[Category: Lcp]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Room temperature structure]]
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[[Category: Serial femtosecond crystallography]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Xfel]]
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Current revision

Human Smoothened Receptor structure in complex with cyclopamine

PDB ID 4o9r

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