6apw

<StructureSection load='6apw' size='340' side='right' caption='[[6apw]], [[Resolution|resolution]] 2.61&Aring;' scene=''>

<table><tr><td colspan='2'>[[6apw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6APW FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTV:4-[(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)methyl]benzoic+acid'>BTV</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">birA, BER48_001399, SAMEA2236422_00088, SAMEA2236459_00088, SAMEA2384800_00088, SAMEA2384856_00382, SAMEA2445640_00088 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6apw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6apw OCA], [http://pdbe.org/6apw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6apw RCSB], [http://www.ebi.ac.uk/pdbsum/6apw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6apw ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/A0A181HT70_STAAU A0A181HT70_STAAU]] Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.[HAMAP-Rule:MF_00978]

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== Publication Abstract from PubMed ==

We report the synthesis and evaluation of 5-halogenated-1,2,3-triazoles as inhibitors of biotin protein ligase from Staphylococcus aureus. The halogenated compounds exhibit significantly improved antibacterial activity over their nonhalogenated counterparts. Importantly, the 5-fluoro-1,2,3-triazole compound 4c displays antibacterial activity against S. aureus ATCC49775 with a minimum inhibitory concentration (MIC) of 8 mug/mL.

 

<div class="pdbe-citations 6apw" style="background-color:#fffaf0;"></div>

== References ==

[[Category: Cini, D A]]

[[Category: Wilce, M C.J]]

[[Category: Antibiotic]]

[[Category: Inhibitor]]

[[Category: Ligase]]