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| - | [[Image:2ekv.jpg|left|200px]] | + | #REDIRECT [[3i5h]] This PDB entry is obsolete and replaced by 3i5h |
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| - | {{Structure
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| - | |PDB= 2ekv |SIZE=350|CAPTION= <scene name='initialview01'>2ekv</scene>, resolution 3.4Å
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| - | |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+C+160'>AC1</scene>
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| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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| - | |ACTIVITY=
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| - | |GENE=
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| - | |DOMAIN=
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| - | |RELATEDENTRY=[[2ekw|2EKW]]
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| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ekv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ekv OCA], [http://www.ebi.ac.uk/pdbsum/2ekv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ekv RCSB]</span>
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| - | }}
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| - | '''The crystal structure of rigor like squid myosin S1 in the absence of nucleotide'''
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| - | ==Overview==
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| - | Unlike processive cellular motors such as myosin V, whose structure has recently been determined in a "rigor-like" conformation, myosin II from contracting muscle filaments necessarily spends most of its time detached from actin. By using squid and sea scallop sources, however, we have now obtained similar rigor-like atomic structures for muscle myosin heads (S1). The significance of the hallmark closed actin-binding cleft in these crystal structures is supported here by actin/S1-binding studies. These structures reveal how different duty ratios, and hence cellular functions, of the myosin isoforms may be accounted for, in part, on the basis of detailed differences in interdomain contacts. Moreover, the rigor-like position of switch II turns out to be unique for myosin V. The overall arrangements of subdomains in the motor are relatively conserved in each of the known contractile states, and we explore qualitatively the energetics of these states.
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| - | ==About this Structure==
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| - | 2EKV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Loligo_pealei Loligo pealei] and [http://en.wikipedia.org/wiki/Todarodes_pacificus Todarodes pacificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EKV OCA].
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| - | ==Reference==
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| - | Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor., Yang Y, Gourinath S, Kovacs M, Nyitray L, Reutzel R, Himmel DM, O'Neall-Hennessey E, Reshetnikova L, Szent-Gyorgyi AG, Brown JH, Cohen C, Structure. 2007 May;15(5):553-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17502101 17502101]
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| - | [[Category: Loligo pealei]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Todarodes pacificus]]
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| - | [[Category: Cohen, C.]]
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| - | [[Category: Neall-Hennessey, E O.]]
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| - | [[Category: Reshetnikova, L.]]
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| - | [[Category: Yang, Y.]]
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| - | [[Category: contractile protein]]
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| - | [[Category: myosin s1]]
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| - | [[Category: nucleotide free]]
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| - | [[Category: rigor-like]]
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| - | [[Category: squid]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:50:39 2008''
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