1op9

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==Complex of human lysozyme with camelid VHH HL6 antibody fragment==
==Complex of human lysozyme with camelid VHH HL6 antibody fragment==
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<StructureSection load='1op9' size='340' side='right' caption='[[1op9]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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<StructureSection load='1op9' size='340' side='right'caption='[[1op9]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1op9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OP9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1op9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OP9 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LYZ OR LZM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1op9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1op9 OCA], [https://pdbe.org/1op9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1op9 RCSB], [https://www.ebi.ac.uk/pdbsum/1op9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1op9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1op9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1op9 OCA], [http://pdbe.org/1op9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1op9 RCSB], [http://www.ebi.ac.uk/pdbsum/1op9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1op9 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[http://omim.org/entry/105200 105200]]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref>
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[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[https://omim.org/entry/105200 105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
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[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1op9_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1op9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1op9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1op9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arabian camel]]
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[[Category: Camelus dromedarius]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Archer, D B]]
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[[Category: Archer DB]]
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[[Category: Canet, D]]
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[[Category: Canet D]]
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[[Category: Decanniere, K]]
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[[Category: Decanniere K]]
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[[Category: Desmyter, A]]
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[[Category: Desmyter A]]
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[[Category: Dobson, C M]]
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[[Category: Dobson CM]]
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[[Category: Dumoulin, M]]
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[[Category: Dumoulin M]]
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[[Category: Larsson, G]]
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[[Category: Larsson G]]
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[[Category: Last, A M]]
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[[Category: Last AM]]
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[[Category: Matagne, A]]
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[[Category: Matagne A]]
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[[Category: Muyldermans, S]]
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[[Category: Muyldermans S]]
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[[Category: Redfield, C]]
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[[Category: Redfield C]]
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[[Category: Robinson, C V]]
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[[Category: Robinson CV]]
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[[Category: Sasse, J]]
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[[Category: Sasse J]]
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[[Category: Spencer, A]]
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[[Category: Spencer A]]
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[[Category: Wyns, L]]
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[[Category: Wyns L]]
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[[Category: Amyloid fibril formation inhibition]]
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[[Category: Antigen-antibody complex]]
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[[Category: Hydrolase]]
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[[Category: Immunoglobulin]]
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Current revision

Complex of human lysozyme with camelid VHH HL6 antibody fragment

PDB ID 1op9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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