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1osn

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==Crystal structure of Varicella zoster virus thymidine kinase in complex with BVDU-MP and ADP==
==Crystal structure of Varicella zoster virus thymidine kinase in complex with BVDU-MP and ADP==
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<StructureSection load='1osn' size='340' side='right' caption='[[1osn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='1osn' size='340' side='right'caption='[[1osn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1osn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-3 Hhv-3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OSN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1osn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_3 Human alphaherpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BVP:(E)-5-(2-BROMOVINYL)-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BVP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BVP:(E)-5-(2-BROMOVINYL)-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BVP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1osn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osn OCA], [http://pdbe.org/1osn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1osn RCSB], [http://www.ebi.ac.uk/pdbsum/1osn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1osn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osn OCA], [https://pdbe.org/1osn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osn RCSB], [https://www.ebi.ac.uk/pdbsum/1osn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KITH_VZVO KITH_VZVO]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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[https://www.uniprot.org/uniprot/KITH_VZVO KITH_VZVO] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1osn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1osn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hhv-3]]
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[[Category: Human alphaherpesvirus 3]]
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[[Category: Thymidine kinase]]
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[[Category: Large Structures]]
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[[Category: Balzarini, J]]
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[[Category: Balzarini J]]
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[[Category: Bird, L E]]
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[[Category: Bird LE]]
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[[Category: Degreve, B]]
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[[Category: Degreve B]]
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[[Category: Leslie, K D]]
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[[Category: Leslie KD]]
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[[Category: Ren, J]]
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[[Category: Ren J]]
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[[Category: Stammers, D K]]
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[[Category: Stammers DK]]
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[[Category: Wright, A]]
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[[Category: Wright A]]
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[[Category: Bvdu-mp]]
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[[Category: Chickenpox]]
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[[Category: Human herpes virus 3]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Varicella zoster virus thymidine kinase in complex with BVDU-MP and ADP

PDB ID 1osn

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