1oqs

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==Crystal Structure of RV4/RV7 Complex==
==Crystal Structure of RV4/RV7 Complex==
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<StructureSection load='1oqs' size='340' side='right' caption='[[1oqs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1oqs' size='340' side='right'caption='[[1oqs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1oqs]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_siamensis Daboia russellii siamensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OQS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1oqs]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_siamensis Daboia siamensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OQS FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqs OCA], [http://pdbe.org/1oqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oqs RCSB], [http://www.ebi.ac.uk/pdbsum/1oqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqs OCA], [https://pdbe.org/1oqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oqs RCSB], [https://www.ebi.ac.uk/pdbsum/1oqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqs ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/PA2A7_DABSI PA2A7_DABSI]] Heterodimer: RV-4/RV-7 targets the presynaptic sites of the neuromuscular junction.<ref>PMID:8835338</ref> Monomer: snake venom phospholipase A2 (PLA2) RV-7 that has low enzymatic activity and is not toxic. It inhibits the enzymatic activity of RV-4 in vitro but potentiates its lethal potency and neurotoxicity. It may facilitate the specific binding of RV-4 to its presynaptic binding sites, probably by acting as a chaperon, minimizing distraction and destruction of RV-4 en route to the site of action by reducing non-specific binding to muscle and other organs. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:8835338</ref> [[http://www.uniprot.org/uniprot/PA2B4_DABSI PA2B4_DABSI]] Heterodimer RV-4/RV-7: acts as a presynaptic neurotoxin. Monomer: snake venom phospholipase A2 (PLA2) that acts as a presynaptic neurotoxin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqs_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1oqs" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1oqs" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Daboia russellii siamensis]]
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[[Category: Daboia siamensis]]
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[[Category: Betzel, C]]
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[[Category: Large Structures]]
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[[Category: Perbandt, M]]
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[[Category: Betzel C]]
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[[Category: Hydrolase]]
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[[Category: Perbandt M]]

Current revision

Crystal Structure of RV4/RV7 Complex

PDB ID 1oqs

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