This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox Reserved 1311
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE== | ==HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE== | ||
<StructureSection load='1b09' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1b09' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | |||
==Human C-Reactive protein== | ==Human C-Reactive protein== | ||
| + | The C-reactive protein is highlighted <scene name='77/777631/C-reactive_protein/1'>here.</scene> | ||
===Function=== | ===Function=== | ||
Human C-reactive protein is a member of the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli."<ref>https://www.ncbi.nlm.nih.gov/gene/1401</ref> | Human C-reactive protein is a member of the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli."<ref>https://www.ncbi.nlm.nih.gov/gene/1401</ref> | ||
| + | |||
| + | ===Structure=== | ||
| + | CRP consists of five identical, noncovalently associated ∼23-kDa protomers arranged symmetrically around a central pore. The term “pentraxins” has been used to describe the family of related proteins with this structure. Each protomer has been found by x-ray crystallography to be folded into two antiparallel β sheets with a flattened jellyroll topology. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. <ref> http://www.jbc.org/content/279/47/48487.full</ref> | ||
| + | |||
| + | One of the protomers of pentaxin <scene name='77/777631/One_protomer/1'>here.</scene> | ||
==Phosphocholine== | ==Phosphocholine== | ||
| - | Phosphocholine serves a binding target for C-reactive protein. | + | Phosphocholine serves a binding target for C-reactive protein. Phosphocholines are highlighted <scene name='77/777631/Phosphocholine/3'>here.</scene> |
===Function=== | ===Function=== | ||
General Function: Low-density lipoprotein particle receptor binding | General Function: Low-density lipoprotein particle receptor binding | ||
| + | |||
Specific Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.<ref>https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine</ref> | Specific Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.<ref>https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine</ref> | ||
===Properties=== | ===Properties=== | ||
Molecular Weight: 184.152 g/mol | Molecular Weight: 184.152 g/mol | ||
| + | |||
Biofluid Locations: blood, breast milk, cerebrospinal fluid, saliva, urine | Biofluid Locations: blood, breast milk, cerebrospinal fluid, saliva, urine | ||
| + | |||
Tissue Locations: Brain, Epidermis, Fibroblasts, Intestine, Kidney, Liver, Placenta, Platelet, Stratum Corneum | Tissue Locations: Brain, Epidermis, Fibroblasts, Intestine, Kidney, Liver, Placenta, Platelet, Stratum Corneum | ||
| + | |||
Cellular location: cytoplasm, exosomes | Cellular location: cytoplasm, exosomes | ||
| - | Target: CRP <ref> https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine </ref> | ||
| - | + | Target: CRP <ref> https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine </ref> | |
| - | The C-reactive protein is highlighted <scene name='77/777631/C-reactive_protein/1'>here.</scene> | ||
| - | Phosphocholines are highlighted <scene name='77/777631/Phosphocholine/3'>here.</scene> | ||
| - | One of the protomers of pentaxin <scene name='77/777631/One_protomer/1'>here.</scene> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE
| |||||||||||
