5wf6

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==Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution==
==Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution==
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<StructureSection load='5wf6' size='340' side='right' caption='[[5wf6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='5wf6' size='340' side='right'caption='[[5wf6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wf6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WF6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WF6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=UKA:6-(2,2-DIPHENYLETHYLAMINO)-9-[(2R,3R,4S,5S)-5-(ETHYLCARBAMOYL)-3,4-DIHYDROXY-OXOLAN-2-YL]-N-[2-[(1-PYRIDIN-2-YLPIPERIDIN-4-YL)CARBAMOYLAMINO]ETHYL]PURINE-2-CARBOXAMIDE'>UKA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=UKA:6-(2,2-DIPHENYLETHYLAMINO)-9-[(2R,3R,4S,5S)-5-(ETHYLCARBAMOYL)-3,4-DIHYDROXY-OXOLAN-2-YL]-N-[2-[(1-PYRIDIN-2-YLPIPERIDIN-4-YL)CARBAMOYLAMINO]ETHYL]PURINE-2-CARBOXAMIDE'>UKA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wf6 OCA], [http://pdbe.org/5wf6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wf6 RCSB], [http://www.ebi.ac.uk/pdbsum/5wf6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wf6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wf6 OCA], [https://pdbe.org/5wf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wf6 RCSB], [https://www.ebi.ac.uk/pdbsum/5wf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wf6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wf6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wf6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lysozyme]]
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[[Category: Escherichia virus T4]]
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[[Category: Deary, A]]
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[[Category: Homo sapiens]]
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[[Category: Eddy, M T]]
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[[Category: Large Structures]]
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[[Category: Gao, Z]]
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[[Category: Deary A]]
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[[Category: Han, G W]]
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[[Category: Eddy MT]]
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[[Category: Hanson, M A]]
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[[Category: Gao Z]]
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[[Category: Jacobson, K A]]
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[[Category: Han GW]]
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[[Category: Katritch, V]]
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[[Category: Hanson MA]]
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[[Category: Lian, T]]
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[[Category: Jacobson KA]]
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[[Category: Patel, N]]
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[[Category: Katritch V]]
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[[Category: Stevens, R C]]
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[[Category: Lian T]]
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[[Category: White, K L]]
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[[Category: Patel N]]
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[[Category: Activation microswitch]]
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[[Category: Stevens RC]]
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[[Category: Agonist]]
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[[Category: White KL]]
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[[Category: Allosteric na-site mutant]]
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[[Category: Gpcr signaling]]
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[[Category: Gpcr-t4l chimera]]
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[[Category: Human a2a adenosine receptor]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: S91a]]
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[[Category: Uk432097]]
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Current revision

Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution

PDB ID 5wf6

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