2ery

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[[Image:2ery.gif|left|200px]]
 
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{{Structure
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==The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state==
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|PDB= 2ery |SIZE=350|CAPTION= <scene name='initialview01'>2ery</scene>, resolution 1.70&Aring;
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<StructureSection load='2ery' size='340' side='right'caption='[[2ery]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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<table><tr><td colspan='2'>[[2ery]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERY FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE= RRAS2, TC21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ery FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ery OCA], [https://pdbe.org/2ery PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ery RCSB], [https://www.ebi.ac.uk/pdbsum/2ery PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ery ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ery FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ery OCA], [http://www.ebi.ac.uk/pdbsum/2ery PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ery RCSB]</span>
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== Disease ==
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}}
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[https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:[https://omim.org/entry/167000 167000]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
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== Function ==
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'''The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state'''
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[https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN] It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2ERY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERY OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2ery_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ery ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Burgess, N.]]
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[[Category: Burgess N]]
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[[Category: Delft, F von.]]
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[[Category: Doyle D]]
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[[Category: Doyle, D.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Salah E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schoch G]]
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[[Category: Salah, E.]]
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[[Category: Soundararajan M]]
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[[Category: Schoch, G.]]
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[[Category: Sundstrom M]]
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[[Category: Soundararajan, M.]]
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[[Category: Turnbull A]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Turnbull, A.]]
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[[Category: Von Delft F]]
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[[Category: Weigel, J.]]
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[[Category: gdp/gtp binding]]
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[[Category: gtp hydrolysis]]
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[[Category: rras2]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:52:58 2008''
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Current revision

The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state

PDB ID 2ery

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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