4v0h
From Proteopedia
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==Human metallo beta lactamase domain containing protein 1 (hMBLAC1)== | ==Human metallo beta lactamase domain containing protein 1 (hMBLAC1)== | ||
| - | <StructureSection load='4v0h' size='340' side='right' caption='[[4v0h]], [[Resolution|resolution]] 1.79Å' scene=''> | + | <StructureSection load='4v0h' size='340' side='right'caption='[[4v0h]], [[Resolution|resolution]] 1.79Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4v0h]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4v0h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V0H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0h OCA], [https://pdbe.org/4v0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v0h RCSB], [https://www.ebi.ac.uk/pdbsum/4v0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v0h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MBLC1_HUMAN MBLC1_HUMAN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo beta-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole endonuclease responsible for 3' end processing of both mRNA classes. We report cellular, genetic, biochemical, substrate selectivity, and crystallographic studies providing evidence that an additional endoribonuclease, MBL domain containing protein 1 (MBLAC1), is selective for 3' processing of RD histone pre-mRNA during the S-phase of the cell cycle. Depletion of MBLAC1 in cells significantly affects cell cycle progression thus identifying MBLAC1 as a new type of S-phase-specific cancer target. | ||
| + | |||
| + | Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.,Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ Elife. 2018 Dec 3;7. pii: 39865. doi: 10.7554/eLife.39865. PMID:30507380<ref>PMID:30507380</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4v0h" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Brem J]] |
| - | + | [[Category: McDonough MA]] | |
| - | + | [[Category: Pettinati I]] | |
| - | [[Category: | + | [[Category: Schofield CJ]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
Current revision
Human metallo beta lactamase domain containing protein 1 (hMBLAC1)
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