2es5

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[[Image:2es5.gif|left|200px]]
 
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{{Structure
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==Structure of the SRE RNA==
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|PDB= 2es5 |SIZE=350|CAPTION= <scene name='initialview01'>2es5</scene>
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<StructureSection load='2es5' size='340' side='right'caption='[[2es5]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[2es5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ES5 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2es5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2es5 OCA], [https://pdbe.org/2es5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2es5 RCSB], [https://www.ebi.ac.uk/pdbsum/2es5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2es5 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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<div style="background-color:#fffaf0;">
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2es5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2es5 OCA], [http://www.ebi.ac.uk/pdbsum/2es5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2es5 RCSB]</span>
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== Publication Abstract from PubMed ==
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}}
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'''Structure of the SRE RNA'''
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==Overview==
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Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.
Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.
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==About this Structure==
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Shape-specific recognition in the structure of the Vts1p SAM domain with RNA.,Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:16429156<ref>PMID:16429156</ref>
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2ES5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA].
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==Reference==
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Shape-specific recognition in the structure of the Vts1p SAM domain with RNA., Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH, Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16429156 16429156]
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[[Category: Protein complex]]
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[[Category: Allain, F H.T.]]
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[[Category: pentaloop]]
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[[Category: rna structure]]
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[[Category: stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:53:06 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2es5" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Allain FHT]]

Current revision

Structure of the SRE RNA

PDB ID 2es5

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