6brd

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==Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complexed with rifampin and FAD==
==Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complexed with rifampin and FAD==
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<StructureSection load='6brd' size='340' side='right' caption='[[6brd]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
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<StructureSection load='6brd' size='340' side='right'caption='[[6brd]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6brd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Strvp Strvp]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5vqc 5vqc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BRD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6brd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae_ATCC_10712 Streptomyces venezuelae ATCC 10712]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5vqc 5vqc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BRD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RFP:RIFAMPICIN'>RFP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vqb|5vqb]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RFP:RIFAMPICIN'>RFP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SVEN_0481 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=953739 STRVP])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6brd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6brd OCA], [https://pdbe.org/6brd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6brd RCSB], [https://www.ebi.ac.uk/pdbsum/6brd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6brd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6brd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6brd OCA], [http://pdbe.org/6brd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6brd RCSB], [http://www.ebi.ac.uk/pdbsum/6brd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6brd ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ROX_STRVP ROX_STRVP] Monooxygenase that can modify rifampicin, thereby inactivating its antibiotic activity (PubMed:29398560). Inactivates a broad range of rifamycin antibiotics (PubMed:29398560).<ref>PMID:29398560</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6brd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6brd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Strvp]]
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[[Category: Large Structures]]
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[[Category: Anderson, W F]]
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[[Category: Streptomyces venezuelae ATCC 10712]]
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[[Category: Structural genomic]]
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[[Category: Anderson WF]]
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[[Category: Cox, G]]
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[[Category: Cox G]]
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[[Category: Kelso, J]]
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[[Category: Kelso J]]
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[[Category: Savchenko, A]]
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[[Category: Savchenko A]]
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[[Category: Stogios, P J]]
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[[Category: Stogios PJ]]
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[[Category: Wright, G D]]
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[[Category: Wright GD]]
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[[Category: Antibiotic resistance]]
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[[Category: Csgid]]
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[[Category: Fad]]
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[[Category: Flavin adenine dinucleotide]]
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[[Category: Monooxygenase]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Oxidoreductase]]
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[[Category: Rifampin]]
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[[Category: Rifamycin]]
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Current revision

Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complexed with rifampin and FAD

PDB ID 6brd

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