This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Sandbox Reserved 1374

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (03:41, 1 March 2018) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
-
==(͡◔ ͜ʖ ͡◔)==
+
==Dystrophin-Glycoprotein Complex==
-
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
+
<StructureSection load='1eg4' size='340' side='right' caption='Caption for this structure' scene=''>
-
<scene name='77/777694/Sandbox_reserved_1374/1'>Believe it or not, that is a DNA sequence.</scene>
+
==Structure==
-
== Function ==
+
The Dystrophin-Glycoprotein Complex (DGC) is named for its glycosylated substituents of the main dystrophin protein. The molecule in its entirety is depicted <scene name='77/777694/Wholeassmolecule/1'>here</scene>. Dystrophin, the largest component of the total complex, is depicted <scene name='77/777694/Dystrophin/1'>here</scene> in blue. One of the most obvious components of dystrophin's structure is its abundance of alpha helices, highlighted <scene name='77/777694/Helix/1'>here</scene> in pink. One of the glycosylated substituents is β-dystroglycan, which is a 15 polypeptide sequence depicted <scene name='77/777694/Beta-dystroglycan/1'>here</scene> in green.
-
Dystrophin is a protein located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). It is a cohesive protein, linking actin filaments to another support protein that resides on the inside surface of each muscle fiber’s plasma membrane (sarcolemma). This support protein on the inside surface of the sarcolemma in turn links to two other consecutive proteins for a total of three linking proteins. The final linking protein is attached to the fibrous endomysium of the entire muscle fiber. Dystrophin supports muscle fiber strength, and the absence of dystrophin reduces muscle stiffness, increases sarcolemmal deformability, and compromises the mechanical stability of costameres and their connections to nearby myofibrils; as shown in recent studies where biomechanical properties of the sarcolemma and its links through costameres to the contractile apparatus were measured,[9] and helps to prevent muscle fiber injury. Movement of thin filaments (actin) creates a pulling force on the extracellular connective tissue that eventually becomes the tendon of the muscle.
+
DGC can be further broken down into three unique subcomplexes. The dystroglycan complex contains both α- and β-dystroglycan molecules. The sarcoglycan complex contains dystrophin-associated glycoproteins. The dystrophin/dystrobrevin/syntrophin complex contains dystrophin-associated proteins.
-
== Disease ==
+
== Function ==
-
Hopefully not
+
Dystrophin is a protein found in the muscle cell. It works to link actin filaments to another protein in the sarcolemma of the muscle's plasma membrane. The protein inside the sarcolemma connects the dystrophin to even more connective proteins to make three total linking proteins. This combination of proteins--with dystrophin playing the most important role-- supports the strength, stability, and overall function of the muscle. If dystrophin is not present, the muscle will become stiff and possibly deformed or at least at an increased risk of injury.
-
== Relevance ==
+
== Diseases ==
-
The codes man!!
+
Defects in the Dystrophin gene are the cause of Duchenne and Becker Muscular Dystrophies (DMD). Muscles that suffer from DMD are significantly low in dystrophin-associated glycoproteins. DMD is characterized by muscle weakness in the hips, pelvic region, and shoulders that lead to skeletal muscle swelling and enlargement. The prime cause of lethality of DMD is when the heart and respiratory muscles lose function. Becker Muscular Dystrophy is a mild version of DMD, spreading slower.
-
== Structural highlights ==
 
-
Its a twisty boy
 
-
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
 
</StructureSection>
</StructureSection>
== References ==
== References ==
-
<references/>
+
https://www.ncbi.nlm.nih.gov/books/NBK6193/

Current revision

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Dystrophin-Glycoprotein Complex

Caption for this structure

Drag the structure with the mouse to rotate

References

https://www.ncbi.nlm.nih.gov/books/NBK6193/

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1374"
Personal tools