This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2eu9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:19, 14 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2eu9.gif|left|200px]]
 
-
{{Structure
+
==Crystal Structure of CLK3==
-
|PDB= 2eu9 |SIZE=350|CAPTION= <scene name='initialview01'>2eu9</scene>, resolution 1.53&Aring;
+
<StructureSection load='2eu9' size='340' side='right'caption='[[2eu9]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
+
<table><tr><td colspan='2'>[[2eu9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EU9 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
-
|GENE= CLK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eu9 OCA], [https://pdbe.org/2eu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eu9 RCSB], [https://www.ebi.ac.uk/pdbsum/2eu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eu9 ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eu9 OCA], [http://www.ebi.ac.uk/pdbsum/2eu9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eu9 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/2eu9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eu9 ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal Structure of CLK3'''
+
==See Also==
-
 
+
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2EU9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EU9 OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Aerrowsmith, C.]]
+
[[Category: Aerrowsmith C]]
-
[[Category: Bullock, A.]]
+
[[Category: Bullock A]]
-
[[Category: Bunkoczi, G.]]
+
[[Category: Bunkoczi G]]
-
[[Category: Das, S.]]
+
[[Category: Das S]]
-
[[Category: Delft, F von.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Fedorov O]]
-
[[Category: Fedorov, O.]]
+
[[Category: Gileadi C]]
-
[[Category: Gileadi, C.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Papagrigoriou, E.]]
+
[[Category: Rellos P]]
-
[[Category: Rellos, P.]]
+
[[Category: Savitsky P]]
-
[[Category: Savitsky, P.]]
+
[[Category: Sobott F]]
-
[[Category: Sobott, F.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Turnbull A]]
-
[[Category: Turnbull, A.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigel, J.]]
+
[[Category: Von Delft F]]
-
[[Category: kinase domain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:53:51 2008''
+

Current revision

Crystal Structure of CLK3

PDB ID 2eu9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2eu9"
Personal tools