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| | ==Solution Structure of a Superantigen from Yersinia pseudotuberculosis== | | ==Solution Structure of a Superantigen from Yersinia pseudotuberculosis== |
| - | <StructureSection load='1poq' size='340' side='right' caption='[[1poq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='1poq' size='340' side='right'caption='[[1poq]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1poq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudotuberkulosis"_(sic)_pfeiffer_1889 "bacillus pseudotuberkulosis" (sic) pfeiffer 1889]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1POQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1poq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis Yersinia pseudotuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1POQ FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ypmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=633 "Bacillus pseudotuberkulosis" (sic) Pfeiffer 1889])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1poq OCA], [http://pdbe.org/1poq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1poq RCSB], [http://www.ebi.ac.uk/pdbsum/1poq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1poq ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1poq OCA], [https://pdbe.org/1poq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1poq RCSB], [https://www.ebi.ac.uk/pdbsum/1poq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1poq ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q57221_YERPU Q57221_YERPU] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Donadini, R]] | + | [[Category: Large Structures]] |
| - | [[Category: Fields, B A]] | + | [[Category: Yersinia pseudotuberculosis]] |
| - | [[Category: Kwan, A H]] | + | [[Category: Donadini R]] |
| - | [[Category: Liew, C W]] | + | [[Category: Fields BA]] |
| - | [[Category: Mackay, J P]] | + | [[Category: Kwan AH]] |
| - | [[Category: Immune system]] | + | [[Category: Liew CW]] |
| - | [[Category: Jelly roll fold]] | + | [[Category: Mackay JP]] |
| Structural highlights
Function
Q57221_YERPU
Publication Abstract from PubMed
Superantigens are a class of microbial proteins with the ability to excessively activate T cells by binding to the T cell receptor. The staphylococcal and streptococcal superantigens are closely related in structure and possess an N-terminal domain that resembles an OB fold and a C-terminal domain similar to a beta-grasp fold. Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other proteins. We have determined the crystal and solution structures of YPMa, which show that the protein has a jelly-roll fold. The closest structural neighbors to YPMa are viral capsid proteins and members of the tumor necrosis factor superfamily. In the crystal structure, YPMa packs as a trimer, another feature shared with viral capsid proteins and TNF superfamily proteins. However, in solution YPMa behaves as a monomer, and any functional relevance of the trimer observed in the crystals is yet to be established.
Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold.,Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA Structure. 2004 Jan;12(1):145-56. PMID:14725774[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA. Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold. Structure. 2004 Jan;12(1):145-56. PMID:14725774
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