1q8d

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==The crystal structure of GDNF family co-receptor alpha 1 domain 3==
==The crystal structure of GDNF family co-receptor alpha 1 domain 3==
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<StructureSection load='1q8d' size='340' side='right' caption='[[1q8d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='1q8d' size='340' side='right'caption='[[1q8d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1q8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1q8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GFRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8d OCA], [https://pdbe.org/1q8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8d RCSB], [https://www.ebi.ac.uk/pdbsum/1q8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8d OCA], [http://pdbe.org/1q8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8d RCSB], [http://www.ebi.ac.uk/pdbsum/1q8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8d ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GFRA1_RAT GFRA1_RAT]] Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
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[https://www.uniprot.org/uniprot/GFRA1_RAT GFRA1_RAT] Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8d_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Bespalov, M M]]
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[[Category: Rattus norvegicus]]
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[[Category: Goldman, A]]
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[[Category: Bespalov MM]]
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[[Category: Leppanen, V M]]
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[[Category: Goldman A]]
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[[Category: Merits, A]]
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[[Category: Leppanen VM]]
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[[Category: Puurand, U]]
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[[Category: Merits A]]
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[[Category: Runeberg-Roos, P]]
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[[Category: Puurand U]]
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[[Category: Saarma, M]]
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[[Category: Runeberg-Roos P]]
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[[Category: All-alpha]]
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[[Category: Saarma M]]
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[[Category: Cys-rich]]
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[[Category: Hormone-growth factor receptor complex]]
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Current revision

The crystal structure of GDNF family co-receptor alpha 1 domain 3

PDB ID 1q8d

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