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1pyy

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==Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution==
==Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution==
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<StructureSection load='1pyy' size='340' side='right' caption='[[1pyy]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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<StructureSection load='1pyy' size='340' side='right'caption='[[1pyy]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1pyy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PYY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1pyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PYY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OSU:N-OCTANOYLSUCROSE'>OSU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qme|1qme]], [[1qmf|1qmf]], [[1k25|1k25]], [[1pmd|1pmd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PRD_900045:octanoyl-sucrose,+esterificated+at+fructose+C6'>PRD_900045</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRV:6-O-octanoyl-beta-D-fructofuranose'>TRV</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PBPX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pyy OCA], [https://pdbe.org/1pyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pyy RCSB], [https://www.ebi.ac.uk/pdbsum/1pyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pyy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pyy OCA], [http://pdbe.org/1pyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pyy RCSB], [http://www.ebi.ac.uk/pdbsum/1pyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pyy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PBPX_STRR6 PBPX_STRR6]] Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
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[https://www.uniprot.org/uniprot/PBPX_STRR6 PBPX_STRR6] Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1pyy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1pyy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Strr6]]
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[[Category: Large Structures]]
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[[Category: Champelovier, D]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Chesnel, L]]
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[[Category: Champelovier D]]
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[[Category: Croize, J]]
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[[Category: Chesnel L]]
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[[Category: Dideberg, O]]
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[[Category: Croize J]]
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[[Category: Lemaire, D]]
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[[Category: Dideberg O]]
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[[Category: Pernot, L]]
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[[Category: Lemaire D]]
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[[Category: Vernet, T]]
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[[Category: Pernot L]]
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[[Category: Zapun, A]]
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[[Category: Vernet T]]
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[[Category: Antibiotic resistance]]
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[[Category: Zapun A]]
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[[Category: Cell wall]]
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[[Category: Penicillin-binding protein]]
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[[Category: Peptidoglycan synthesis]]
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[[Category: Transmembrane]]
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[[Category: Transpeptidase]]
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Current revision

Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution

PDB ID 1pyy

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