This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2exe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:40, 23 August 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2exe.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of the phosphorylated CLK3==
-
|PDB= 2exe |SIZE=350|CAPTION= <scene name='initialview01'>2exe</scene>, resolution 2.35&Aring;
+
<StructureSection load='2exe' size='340' side='right'caption='[[2exe]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2exe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXE FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-
|GENE= CLK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exe OCA], [https://pdbe.org/2exe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exe RCSB], [https://www.ebi.ac.uk/pdbsum/2exe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exe ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=[[2eu9|2EU9]]
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exe OCA], [http://www.ebi.ac.uk/pdbsum/2exe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2exe RCSB]</span>
+
[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref>
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exe_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exe ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of the phosphorylated CLK3'''
+
==See Also==
-
 
+
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2EXE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXE OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Ball, L J.]]
+
[[Category: Ball LJ]]
-
[[Category: Bullock, A.]]
+
[[Category: Bullock A]]
-
[[Category: Das, S.]]
+
[[Category: Das S]]
-
[[Category: Delft, F von.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Fedorov O]]
-
[[Category: Fedorov, O.]]
+
[[Category: Johansson C]]
-
[[Category: Johansson, C.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Papagrigoriou, E.]]
+
[[Category: Rellos P]]
-
[[Category: Rellos, P.]]
+
[[Category: Savitsky P]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Sobott F]]
-
[[Category: Savitsky, P.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sobott, F.]]
+
[[Category: Turnbull A]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Turnbull, A.]]
+
[[Category: Weigelt J]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Von Delft F]]
-
[[Category: Weigel, J.]]
+
-
[[Category: dual-specificity kinase]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomic]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:55:04 2008''
+

Current revision

Crystal structure of the phosphorylated CLK3

PDB ID 2exe

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2exe"
Personal tools