5qfk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5qfk is ON HOLD Authors: Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000509a== | |
| + | <StructureSection load='5qfk' size='340' side='right'caption='[[5qfk]], [[Resolution|resolution]] 1.59Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5qfk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QFK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.594Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJP:(2S,5S,6R)-7-methyl-2,3,4,5,6,7-hexahydro-1H-2,6-methanoazocino[5,4-b]indol-5-ol'>JJP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qfk OCA], [https://pdbe.org/5qfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qfk RCSB], [https://www.ebi.ac.uk/pdbsum/5qfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qfk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Brandao-Neto | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Biel JT]] |
| - | [[Category: | + | [[Category: Brandao-Neto J]] |
| - | [[Category: | + | [[Category: Fraser JS]] |
| - | [[Category: | + | [[Category: Hill ZB]] |
| - | [[Category: Von Delft | + | [[Category: Kang E]] |
| + | [[Category: Keedy DA]] | ||
| + | [[Category: Rettenmaier TJ]] | ||
| + | [[Category: Wells JA]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000509a
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Categories: Homo sapiens | Large Structures | Biel JT | Brandao-Neto J | Fraser JS | Hill ZB | Kang E | Keedy DA | Rettenmaier TJ | Wells JA | Von Delft F
