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5zcj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of complex== | |
| - | + | <StructureSection load='5zcj' size='340' side='right'caption='[[5zcj]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5zcj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZCJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.004Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zcj OCA], [https://pdbe.org/5zcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zcj RCSB], [https://www.ebi.ac.uk/pdbsum/5zcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zcj ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cui Y]] | ||
| + | [[Category: Liu X]] | ||
| + | [[Category: Ma Y]] | ||
| + | [[Category: Wang J]] | ||
| + | [[Category: Wang M]] | ||
| + | [[Category: Xie R]] | ||
| + | [[Category: Yu X]] | ||
| + | [[Category: Yuan Z]] | ||
Current revision
Crystal structure of complex
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Categories: Homo sapiens | Large Structures | Cui Y | Liu X | Ma Y | Wang J | Wang M | Xie R | Yu X | Yuan Z
