5mtk

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==Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)==
==Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)==
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<StructureSection load='5mtk' size='340' side='right' caption='[[5mtk]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
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<StructureSection load='5mtk' size='340' side='right'caption='[[5mtk]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mtk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MTK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mtk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MTK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N7N:(3~{S})-3-[[(3~{S},6~{S},10~{a}~{S})-6-(isoquinolin-1-ylcarbonylamino)-5-oxidanylidene-2,3,6,7,8,9,10,10~{a}-octahydro-1~{H}-pyrrolo[1,2-a]azocin-3-yl]carbonylamino]-4-oxidanyl-butanoic+acid'>N7N</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N7N:(3~{S})-3-[[(3~{S},6~{S},10~{a}~{S})-6-(isoquinolin-1-ylcarbonylamino)-5-oxidanylidene-2,3,6,7,8,9,10,10~{a}-octahydro-1~{H}-pyrrolo[1,2-a]azocin-3-yl]carbonylamino]-4-oxidanyl-butanoic+acid'>N7N</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mtk OCA], [http://pdbe.org/5mtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mtk RCSB], [http://www.ebi.ac.uk/pdbsum/5mtk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mtk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mtk OCA], [https://pdbe.org/5mtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mtk RCSB], [https://www.ebi.ac.uk/pdbsum/5mtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mtk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
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[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
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==See Also==
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caspase-1]]
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[[Category: Homo sapiens]]
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[[Category: Brethon, A]]
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[[Category: Large Structures]]
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[[Category: Chantalat, L]]
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[[Category: Brethon A]]
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[[Category: Christin, O]]
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[[Category: Chantalat L]]
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[[Category: Clary, L]]
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[[Category: Christin O]]
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[[Category: Fournier, J F]]
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[[Category: Clary L]]
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[[Category: Gastreich, M]]
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[[Category: Fournier JF]]
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[[Category: Harris, C]]
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[[Category: Gastreich M]]
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[[Category: Isabet, T]]
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[[Category: Harris C]]
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[[Category: Pascau, J]]
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[[Category: Isabet T]]
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[[Category: Roche, D]]
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[[Category: Pascau J]]
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[[Category: Rodeschin, V]]
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[[Category: Roche D]]
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[[Category: Thoreau, E]]
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[[Category: Rodeschin V]]
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[[Category: Hydrolase]]
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[[Category: Thoreau E]]
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[[Category: Inflammatory disease]]
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[[Category: Nanomolar inhibitor]]
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[[Category: Sp3 hybridization]]
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Current revision

Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)

PDB ID 5mtk

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OCA

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