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2vsm

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==Nipah virus attachment glycoprotein in complex with human cell surface receptor ephrinB2==
==Nipah virus attachment glycoprotein in complex with human cell surface receptor ephrinB2==
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<StructureSection load='2vsm' size='340' side='right' caption='[[2vsm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='2vsm' size='340' side='right'caption='[[2vsm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Nipav Nipav]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VSM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Nipah_henipavirus Nipah henipavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vsk|2vsk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsm OCA], [https://pdbe.org/2vsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsm RCSB], [https://www.ebi.ac.uk/pdbsum/2vsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsm OCA], [http://pdbe.org/2vsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vsm RCSB], [http://www.ebi.ac.uk/pdbsum/2vsm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLYCP_NIPAV GLYCP_NIPAV]] Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:17470910</ref> <ref>PMID:15961384</ref> [[http://www.uniprot.org/uniprot/EFNB2_HUMAN EFNB2_HUMAN]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.<ref>PMID:12734395</ref>
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[https://www.uniprot.org/uniprot/GLYCP_NIPAV GLYCP_NIPAV] Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:17470910</ref> <ref>PMID:15961384</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Ephrin|Ephrin]]
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Nipav]]
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[[Category: Nipah henipavirus]]
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[[Category: Aricescu, A R]]
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[[Category: Aricescu AR]]
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[[Category: Bowden, T A]]
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[[Category: Bowden TA]]
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[[Category: Gilbert, R J]]
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[[Category: Gilbert RJ]]
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[[Category: Grimes, J M]]
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[[Category: Grimes JM]]
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[[Category: Jones, E Y]]
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[[Category: Jones EY]]
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[[Category: Stuart, D I]]
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[[Category: Stuart DI]]
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[[Category: B2]]
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[[Category: Cell surface receptor]]
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[[Category: Complex]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Efn]]
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[[Category: Envelope protein]]
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[[Category: Eph]]
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[[Category: Ephrin]]
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[[Category: Glycoprotein]]
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[[Category: Hemagglutinin]]
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[[Category: Hendra]]
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[[Category: Henipavirus]]
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[[Category: Hev]]
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[[Category: Hev-g]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Neurogenesis]]
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[[Category: Nipah]]
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[[Category: Niv]]
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[[Category: Niv-g]]
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[[Category: Paramyxovirus]]
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[[Category: Phosphoprotein]]
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[[Category: Signal-anchor]]
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[[Category: Transmembrane]]
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[[Category: Viral attachment]]
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[[Category: Virion]]
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[[Category: Virus]]
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Current revision

Nipah virus attachment glycoprotein in complex with human cell surface receptor ephrinB2

PDB ID 2vsm

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