1rcv

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==Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1==
==Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1==
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<StructureSection load='1rcv' size='340' side='right' caption='[[1rcv]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='1rcv' size='340' side='right'caption='[[1rcv]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1rcv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RCV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RCV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1rcv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RCV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BV1:[3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO]+-2-(3-{4-[3-(3-NITRO-5-[GALACTOPYRANOSYLOXY]-BENZOYLAMINO)-PROPYL]-PIPERAZIN-1-YL}+-PROPYL-AMINO)-3,4-DIOXO-CYCLOBUTENE'>BV1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rd9|1rd9]], [[1rdp|1rdp]], [[1rf2|1rf2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BV1:3-(alpha-D-galactopyranosyloxy)-N-(3-{4-[3-({2-[(3-{4-[3-({[3-(hexopyranosyloxy)-5-nitrophenyl]carbonyl}amino)propyl]piperazin-1-yl}propyl)amino]-3,4-dioxocyclobut-1-en-1-yl}amino)propyl]piperazin-1-yl}propyl)-5-nitrobenzamide'>BV1</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ctxB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rcv OCA], [https://pdbe.org/1rcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rcv RCSB], [https://www.ebi.ac.uk/pdbsum/1rcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rcv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rcv OCA], [http://pdbe.org/1rcv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rcv RCSB], [http://www.ebi.ac.uk/pdbsum/1rcv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rcv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
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[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Cholera toxin|Cholera toxin]]
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*[[Cholera toxin 3D structures|Cholera toxin 3D structures]]
*[[User:David Solfiell/sandbox 1|User:David Solfiell/sandbox 1]]
*[[User:David Solfiell/sandbox 1|User:David Solfiell/sandbox 1]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillo virgola del koch trevisan 1884]]
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[[Category: Large Structures]]
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[[Category: Fan, E]]
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[[Category: Vibrio cholerae]]
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[[Category: Hol, W G]]
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[[Category: Fan E]]
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[[Category: Liu, J]]
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[[Category: Hol WG]]
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[[Category: Mitchell, D D]]
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[[Category: Liu J]]
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[[Category: Pickens, J C]]
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[[Category: Mitchell DD]]
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[[Category: Tan, X]]
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[[Category: Pickens JC]]
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[[Category: Verlinde, C L]]
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[[Category: Tan X]]
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[[Category: Zhang, Z]]
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[[Category: Verlinde CL]]
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[[Category: Bivalent]]
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[[Category: Zhang Z]]
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[[Category: Cholera]]
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[[Category: Complex]]
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[[Category: Pentamer]]
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[[Category: Toxin]]
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Current revision

Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1

PDB ID 1rcv

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