2f6q

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[[Image:2f6q.gif|left|200px]]
 
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{{Structure
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==The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)==
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|PDB= 2f6q |SIZE=350|CAPTION= <scene name='initialview01'>2f6q</scene>, resolution 1.95&Aring;
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<StructureSection load='2f6q' size='340' side='right'caption='[[2f6q]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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<table><tr><td colspan='2'>[[2f6q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F6Q FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dodecenoyl-CoA_isomerase Dodecenoyl-CoA isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.8 5.3.3.8] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE= PECI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6q OCA], [https://pdbe.org/2f6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f6q RCSB], [https://www.ebi.ac.uk/pdbsum/2f6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f6q ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6q OCA], [http://www.ebi.ac.uk/pdbsum/2f6q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f6q RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/ECI2_HUMAN ECI2_HUMAN] Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).
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== Evolutionary Conservation ==
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'''The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6q_consurf.spt"</scriptWhenChecked>
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2F6Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6Q OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Dodecenoyl-CoA isomerase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f6q ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Berridge, G.]]
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[[Category: Berridge G]]
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[[Category: Delft, F von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Guo K]]
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[[Category: Guo, K.]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Shafqat N]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Smee C]]
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[[Category: Shafqat, N.]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C.]]
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[[Category: Turnbull A]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Turnbull, A.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: enoyl coa isomerase]]
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[[Category: fatty acid metabolism]]
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[[Category: peroxisome]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:58:41 2008''
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Current revision

The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)

PDB ID 2f6q

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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