Adenylosuccinate lyase

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== Structural highlights ==
== Structural highlights ==
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The ASL can be divided into 3 domains. The <scene name='75/751814/Cv/4'>active site</scene> is situated between the 3 domains and contains the product AMP and and oxalate<ref>PMID:20693687</ref>. <scene name='75/751814/Cv/5'>Oxalate binding</scene>.
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The ASL can be divided into 3 domains. The <scene name='75/751814/Cv/6'>active site</scene> is situated between the 3 domains and contains the product AMP and and oxalate<ref>PMID:20693687</ref>. Water molecules are shown as red spheres. <scene name='75/751814/Cv/7'>Oxalate binding</scene>.
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</StructureSection>
 
==3D structures of adenylosuccinate lyase==
==3D structures of adenylosuccinate lyase==
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[[Adenylosuccinate lyase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Adenylosuccinate lyase
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**[[5eyv]] – SmASL – ''Schistosoma mansoni''<br />
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**[[4nle]] – ASL – ''Mycobacterium smegmatis''<br />
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**[[4ffx]], [[4flc]] – hASL (mutant) – human<br />
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**[[5e3v]], [[4nsl]] – ASL – ''Salmonella typhimurium''<br />
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**[[3gzh]], [[2pts]] – EcASL – ''Escherichia coli''<br />
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**[[3bhg]] – ASL – ''Legionella pneumophila''<br />
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**[[2hvg]] – PvASL – ''Plasmodium vivax''<br />
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**[[1yis]] – ASL – ''Caernohabditis elegans''<br />
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**[[1dof]] – ASL – ''Pyrobaculum aerophilum''<br />
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**[[1f1o]] – ASL – ''Bacillus subtilis''<br />
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**[[1c3u]], [[1c3c]] – ASL – ''Termotoga maritima''<br />
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**[[5v4l]] – ASL – ''Cryptococcus neoformans''<br />
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**[[5vkw]] – ASL – ''Candida albicans''<br />
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*Adenylosuccinate lyase binary complex
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**[[5eyt]] – SmASL + AMP <br />
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**[[2j91]] – hASL + AMP <br />
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**[[4mx2]] – ASL + AMP – ''Leishmania donovani''<br />
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**[[4efc]] – ASL + AMP – ''Trypanosoma brucei''<br />
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**[[2qga]] – PvASL + AMP <br />
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**[[2ptr]] – EcASL (mutant) + substrate <br />
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**[[2pfm]] – ASL + malonate – ''Bacillus anthracis''<br />
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**[[5e3v]], [[5hw2]] – FtASL + fumarate - ''Francisella tularensis'' <br />
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*Adenylosuccinate lyase higher complexes
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**[[2x75]] – ASL + AMP + oxalate – ''Staphylococcus aureus''<br />
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**[[4eei]] – FtASL + AMP + succinate <br />
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**[[2ptq]] – EcASL (mutant) + fumarate + AMP <br />
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**[[2vd6]] – hASL + fumarate + AMP + dicarboxymethyl-AMP<br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Adenylsuccinate lyase complex with AMP, oxalate, PEG 400 and Cl- ion (green) (PDB code 2x75)

Drag the structure with the mouse to rotate

References

  1. ↑ Kmoch S, Hartmannova H, Stiburkova B, Krijt J, Zikanova M, Sebesta I. Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients. Hum Mol Genet. 2000 Jun 12;9(10):1501-13. PMID:10888601
  2. ↑ Mierzewska H, Schmidt-Sidor B, Jurkiewicz E, Bogdanska A, Kusmierska K, Stepien T. Severe encephalopathy with brain atrophy and hypomyelination due to adenylosuccinate lyase deficiency--MRI, clinical, biochemical and neuropathological findings of Polish patients. Folia Neuropathol. 2009;47(4):314-20. PMID:20054783
  3. ↑ Fyfe PK, Dawson A, Hutchison MT, Cameron S, Hunter WN. Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery. Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):881-8. Epub 2010, Jul 9. PMID:20693687 doi:10.1107/S0907444910020081

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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