6fqg

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(New page: '''Unreleased structure''' The entry 6fqg is ON HOLD until Paper Publication Authors: Coombs, I.D., Soto, D., Gold, M.G., Farrant, M.F., Cull-Candy, S.G. Description: GluA2(flop) G724C...)
Current revision (07:48, 7 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6fqg is ON HOLD until Paper Publication
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==GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution==
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<StructureSection load='6fqg' size='340' side='right'caption='[[6fqg]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6fqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FQG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3413908&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fqg OCA], [https://pdbe.org/6fqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fqg RCSB], [https://www.ebi.ac.uk/pdbsum/6fqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fqg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
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Authors: Coombs, I.D., Soto, D., Gold, M.G., Farrant, M.F., Cull-Candy, S.G.
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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Description: GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Gold, M.G]]
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__TOC__
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[[Category: Cull-Candy, S.G]]
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</StructureSection>
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[[Category: Farrant, M.F]]
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[[Category: Large Structures]]
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[[Category: Soto, D]]
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[[Category: Rattus norvegicus]]
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[[Category: Coombs, I.D]]
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[[Category: Coombs ID]]
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[[Category: Cull-Candy SG]]
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[[Category: Farrant MF]]
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[[Category: Gold MG]]
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[[Category: Soto D]]

Current revision

GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution

PDB ID 6fqg

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