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5nu7

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==Structure of human holo plasma RBP4==
==Structure of human holo plasma RBP4==
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<StructureSection load='5nu7' size='340' side='right' caption='[[5nu7]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='5nu7' size='340' side='right'caption='[[5nu7]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nu7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NU7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nu7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NU7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1brp|1brp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nu7 OCA], [http://pdbe.org/5nu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nu7 RCSB], [http://www.ebi.ac.uk/pdbsum/5nu7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nu7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nu7 OCA], [https://pdbe.org/5nu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nu7 RCSB], [https://www.ebi.ac.uk/pdbsum/5nu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nu7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nu7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nu7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Galliano, M]]
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[[Category: Large Structures]]
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[[Category: Monaco, H L]]
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[[Category: Galliano M]]
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[[Category: Perduca, M]]
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[[Category: Monaco HL]]
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[[Category: Lipocalin]]
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[[Category: Perduca M]]
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[[Category: Plasma retinol-binding protein]]
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[[Category: Rbp4]]
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[[Category: Retinol]]
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[[Category: Transport protein]]
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Current revision

Structure of human holo plasma RBP4

PDB ID 5nu7

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