6ccf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:01, 4 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of the Human CAMKK1A in complex with Hesperadin==
==Crystal Structure of the Human CAMKK1A in complex with Hesperadin==
-
<StructureSection load='6ccf' size='340' side='right' caption='[[6ccf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+
<StructureSection load='6ccf' size='340' side='right'caption='[[6ccf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6ccf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CCF FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6ccf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CCF FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H1N:N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE'>H1N</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H1N:N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE'>H1N</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccf OCA], [http://pdbe.org/6ccf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ccf RCSB], [http://www.ebi.ac.uk/pdbsum/6ccf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccf ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccf OCA], [https://pdbe.org/6ccf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ccf RCSB], [https://www.ebi.ac.uk/pdbsum/6ccf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN]] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref>
+
[https://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref>
 +
 
 +
==See Also==
 +
*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Calcium/calmodulin-dependent protein kinase]]
+
[[Category: Homo sapiens]]
-
[[Category: Arruda, P]]
+
[[Category: Large Structures]]
-
[[Category: Counago, R M]]
+
[[Category: Arruda P]]
-
[[Category: Drewry, D]]
+
[[Category: Counago RM]]
-
[[Category: Edwards, A M]]
+
[[Category: Drewry D]]
-
[[Category: Elkins, J M]]
+
[[Category: Edwards AM]]
-
[[Category: Massirer, K B]]
+
[[Category: Elkins JM]]
-
[[Category: Ramos, P Z]]
+
[[Category: Massirer KB]]
-
[[Category: Reis, C V.dos]]
+
[[Category: Ramos PZ]]
-
[[Category: Structural genomic]]
+
[[Category: Santiago AS]]
-
[[Category: Santiago, A S]]
+
[[Category: Silva PNB]]
-
[[Category: Silva, P N.B]]
+
[[Category: Dos Reis CV]]
-
[[Category: Protein kinase domain]]
+
-
[[Category: Psi-biology]]
+
-
[[Category: Sgc]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Current revision

Crystal Structure of the Human CAMKK1A in complex with Hesperadin

PDB ID 6ccf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ccf"
Personal tools