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2xb5

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==Tet repressor (class D) in complex with 7-Iodotetracycline==
==Tet repressor (class D) in complex with 7-Iodotetracycline==
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<StructureSection load='2xb5' size='340' side='right' caption='[[2xb5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2xb5' size='340' side='right'caption='[[2xb5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x6o|2x6o]], [[1a6i|1a6i]], [[2x9d|2x9d]], [[1bjz|1bjz]], [[1qpi|1qpi]], [[2vke|2vke]], [[2trt|2trt]], [[2vkv|2vkv]], [[1ork|1ork]], [[1bj0|1bj0]], [[2tct|2tct]], [[1bjy|1bjy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [http://pdbe.org/2xb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [https://pdbe.org/2xb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
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[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Tetracycline repressor protein|Tetracycline repressor protein]]
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Hinrichs, W]]
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[[Category: Large Structures]]
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[[Category: Kisker, C]]
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[[Category: Hinrichs W]]
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[[Category: Saenger, W]]
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[[Category: Kisker C]]
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[[Category: Antibiotic resistance]]
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[[Category: Saenger W]]
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[[Category: Metal-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Tet repressor (class D) in complex with 7-Iodotetracycline

PDB ID 2xb5

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