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4s3b

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==IspG in complex with Intermediate II==
==IspG in complex with Intermediate II==
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<StructureSection load='4s3b' size='340' side='right' caption='[[4s3b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4s3b' size='340' side='right'caption='[[4s3b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4s3b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S3B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4s3b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S3B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43Q:(3S)-1,3-DIHYDROXY-4-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-2-METHYLBUT-2-YLIUM,+CARBOKATION+INTERMEDIATE'>43Q</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43Q:(3S)-1,3-DIHYDROXY-4-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-2-METHYLBUT-2-YLIUM,+CARBOKATION+INTERMEDIATE'>43Q</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g9p|4g9p]], [[2y0f|2y0f]], [[3noy|3noy]], [[4s38|4s38]], [[4s39|4s39]], [[4s3a|4s3a]], [[4s3c|4s3c]], [[4s3d|4s3d]], [[4s3e|4s3e]], [[4s3f|4s3f]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s3b OCA], [https://pdbe.org/4s3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s3b RCSB], [https://www.ebi.ac.uk/pdbsum/4s3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s3b ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ispG, TTHA0305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate_synthase (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.7.1 1.17.7.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s3b OCA], [http://pdbe.org/4s3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s3b RCSB], [http://www.ebi.ac.uk/pdbsum/4s3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s3b ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ISPG_THET8 ISPG_THET8]] Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
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[https://www.uniprot.org/uniprot/ISPG_THET8 ISPG_THET8] Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thet8]]
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[[Category: Large Structures]]
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[[Category: Abdel-Azeim, S]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Bacher, A]]
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[[Category: Abdel-Azeim S]]
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[[Category: Dowd, B O]]
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[[Category: Bacher A]]
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[[Category: Eppinger, J]]
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[[Category: Eppinger J]]
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[[Category: Frank, A]]
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[[Category: Frank A]]
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[[Category: Groll, M]]
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[[Category: Groll M]]
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[[Category: Guerra, F]]
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[[Category: Guerra F]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Oldfield, E]]
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[[Category: O'Dowd B]]
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[[Category: Quitterer, F]]
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[[Category: Oldfield E]]
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[[Category: Rao, G]]
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[[Category: Quitterer F]]
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[[Category: Wang, K]]
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[[Category: Rao G]]
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[[Category: Drug development]]
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[[Category: Wang K]]
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[[Category: Iron-sulfur enzyme]]
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[[Category: Methylerythritol-phosphate pathway]]
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[[Category: Oxidoreductase]]
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[[Category: Reaction mechanism]]
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[[Category: Terpene biosynthesis]]
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Current revision

IspG in complex with Intermediate II

PDB ID 4s3b

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