1s5i
From Proteopedia
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==Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure== | ==Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure== | ||
| - | <StructureSection load='1s5i' size='340' side='right' caption='[[1s5i]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='1s5i' size='340' side='right'caption='[[1s5i]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1s5i]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1s5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5I FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5i OCA], [https://pdbe.org/1s5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5i RCSB], [https://www.ebi.ac.uk/pdbsum/1s5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5i ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IGH1M_MOUSE IGH1M_MOUSE] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5i_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5i_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s5i ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s5i ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in a new crystal form (space group P2(1)2(1)2(1); unit cell parameters: a = 42.82, b = 90.68, and c = 139.82 A) was determined by the X-ray molecular replacement method at the resolution of 2.7 A. The protein folding and the stereochemistry of its antigen-binding site were comparatively analyzed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru. | ||
| - | == | + | [A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2: the three-dimensional structure at 2.7 A resolution].,Pletnev VZ, Goriacheva EA, Tsygannik IN, Nesmeianov VA, Pletnev SV, Pangborn W, Daux W Bioorg Khim. 2004 Sep-Oct;30(5):466-9. PMID:15562966<ref>PMID:15562966</ref> |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 1s5i" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Duax | + | [[Category: Duax W]] |
| - | [[Category: Goryacheva | + | [[Category: Goryacheva EA]] |
| - | [[Category: Nesmeyanov | + | [[Category: Nesmeyanov VA]] |
| - | [[Category: Pangborn | + | [[Category: Pangborn W]] |
| - | [[Category: Pletnev | + | [[Category: Pletnev SV]] |
| - | [[Category: Pletnev | + | [[Category: Pletnev VZ]] |
| - | [[Category: Tsygannik | + | [[Category: Tsygannik IN]] |
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Current revision
Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure
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