2fgt

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[[Image:2fgt.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of YycH from Bacillus subtilis==
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|PDB= 2fgt |SIZE=350|CAPTION= <scene name='initialview01'>2fgt</scene>, resolution 2.3&Aring;
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<StructureSection load='2fgt' size='340' side='right'caption='[[2fgt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2fgt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FGT FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE= yycH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgt OCA], [https://pdbe.org/2fgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fgt RCSB], [https://www.ebi.ac.uk/pdbsum/2fgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fgt ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgt OCA], [http://www.ebi.ac.uk/pdbsum/2fgt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fgt RCSB]</span>
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[https://www.uniprot.org/uniprot/YYCH_BACSU YYCH_BACSU] Together with YycI, regulates the activity of the two-component system YycF/YycG.<ref>PMID:17307850</ref> <ref>PMID:18408157</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Crystal Structure of YycH from Bacillus subtilis'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/2fgt_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The Bacillus subtilis YycFG two-component signal transduction system is essential for cell viability, and the YycH protein is part of the regulatory circuit that controls its activity. The crystal structure of YycH was solved by two-wavelength selenium anomalous dispersion data, and was refined using 2.3 A data to an R-factor of 25.2%. The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fgt ConSurf].
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2FGT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGT OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure., Szurmant H, Zhao H, Mohan MA, Hoch JA, Varughese KI, Protein Sci. 2006 Apr;15(4):929-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16600972 16600972]
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: James, H A.]]
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[[Category: James HA]]
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[[Category: Mohan, M A.]]
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[[Category: Mohan MA]]
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[[Category: Szurmant, H.]]
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[[Category: Szurmant H]]
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[[Category: Varughese, K I.]]
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[[Category: Varughese KI]]
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[[Category: Zhao, H.]]
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[[Category: Zhao H]]
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[[Category: beta sheet]]
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[[Category: calcium binding]]
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[[Category: signal transduction]]
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[[Category: yych]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:02:33 2008''
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Current revision

Crystal Structure of YycH from Bacillus subtilis

PDB ID 2fgt

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OCA

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