1s1j
From Proteopedia
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==Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1== | ==Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1== | ||
| - | <StructureSection load='1s1j' size='340' side='right' caption='[[1s1j]], [[Resolution|resolution]] 2.18Å' scene=''> | + | <StructureSection load='1s1j' size='340' side='right'caption='[[1s1j]], [[Resolution|resolution]] 2.18Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1s1j]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1s1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1J FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQZ:(12BS)-1,2,3,4,12,12B-HEXAHYDROINDOLO[2,3-A]QUINOLIZIN-7(6H)-ONE'>IQZ</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1j OCA], [https://pdbe.org/1s1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1j RCSB], [https://www.ebi.ac.uk/pdbsum/1s1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1j ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509] |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1j ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1j ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water. | ||
| - | + | ==See Also== | |
| - | + | *[[Cell division protein 3D structures|Cell division protein 3D structures]] | |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ding W]] |
| - | [[Category: | + | [[Category: Dushin EG]] |
| - | [[Category: | + | [[Category: Foreman KW]] |
| - | [[Category: Jenning | + | [[Category: Jenning LD]] |
| - | [[Category: Kenney | + | [[Category: Kenney CH]] |
| - | [[Category: Li | + | [[Category: Li Y]] |
| - | [[Category: Moghazeh | + | [[Category: Moghazeh SL]] |
| - | [[Category: Mosyak | + | [[Category: Mosyak L]] |
| - | [[Category: Peterson | + | [[Category: Peterson PJ]] |
| - | [[Category: | + | [[Category: Rush III TS]] |
| - | [[Category: | + | [[Category: Ruzin AV]] |
| - | [[Category: | + | [[Category: Sukhdeo MN]] |
| - | [[Category: | + | [[Category: Sutherland AG]] |
| - | [[Category: | + | [[Category: Tsao DH]] |
| - | [[Category: | + | [[Category: Tuckman M]] |
Current revision
Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1
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Categories: Escherichia coli | Large Structures | Ding W | Dushin EG | Foreman KW | Jenning LD | Kenney CH | Li Y | Moghazeh SL | Mosyak L | Peterson PJ | Rush III TS | Ruzin AV | Sukhdeo MN | Sutherland AG | Tsao DH | Tuckman M
