Agglutinin

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Current revision

Agglutinin complex with polysaccharide of α- and β-mannose, imidazole and Na+ ion (purple) (PDB code 4gk9)

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References

↑ Dalla Pellegrina C, Perbellini O, Scupoli MT, Tomelleri C, Zanetti C, Zoccatelli G, Fusi M, Peruffo A, Rizzi C, Chignola R. Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction. Toxicol Appl Pharmacol. 2009 Jun 1;237(2):146-53. doi:, 10.1016/j.taap.2009.03.012. Epub 2009 Mar 28. PMID:19332085 doi:http://dx.doi.org/10.1016/j.taap.2009.03.012
↑ Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013 Aug 15;122(7):1114-21. doi: 10.1182/blood-2013-02-474437. Epub 2013, Jun 11. PMID:23757733 doi:http://dx.doi.org/10.1182/blood-2013-02-474437
↑ Whitley MJ, Furey W, Kollipara S, Gronenborn AM. Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding and anti-HIV activity. FEBS J. 2013 May;280(9):2056-67. doi: 10.1111/febs.12229. Epub 2013 Apr 2. PMID:23480609 doi:10.1111/febs.12229

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Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Agglutinin"

Category: Topic Page

@@ Line 1: / Line 1: @@
 <StructureSection load='' size='450' side='right' caption='Agglutinin complex with polysaccharide of α- and β-mannose, imidazole and Na+ ion (purple) (PDB code [[4gk9]])' scene='74/749490/Cv/1'>
+__TOC__
 == Function ==
-'''Agglutinin'''s (AGG) are sugar-binding lectins which cause particles to change from fluid state to thickened-mass state.  '''Agglutinin isolectin''' or '''wheat germ agglutinin''' is a plant protein that binds specifically to sugars expressed by human gastrointestinal epithelial and immune cells<ref>PMID:19332085</ref>.
+'''Agglutinin'''s or '''galactose-inding lectin''' (AGG) are sugar-binding lectins which cause particles to change from fluid state to thickened-mass state.  '''Agglutinin isolectin''' or '''wheat germ agglutinin''' is a plant protein that binds specifically to sugars expressed by human gastrointestinal epithelial and immune cells<ref>PMID:19332085</ref>.
 == Disease ==
@@ Line 10: / Line 10: @@
 == Structural highlights ==
 Agglutinin binds polysaccharide composed of α- and β-mannose in its active site<ref>PMID:23480609</ref>.
-*<scene name='74/749490/Cv/2'>1st poly-mannose binding site</scene>.
+*<scene name='74/749490/Cv/6'>1st poly-mannose binding site</scene>.
-*<scene name='74/749490/Cv/3'>2nd poly-mannose binding site</scene>.
+*<scene name='74/749490/Cv/7'>2nd poly-mannose binding site</scene>.
-*<scene name='74/749490/Cv/4'>3rd poly-mannose binding site</scene>.
+*<scene name='74/749490/Cv/8'>3rd poly-mannose binding site</scene>.
-*<scene name='74/749490/Cv/5'>4th poly-mannose binding site</scene>.
+*<scene name='74/749490/Cv/9'>4th poly-mannose binding site</scene>.
+== 3D Structures of agglutinin ==
+[[Agglutinin 3D structures]]
 </StructureSection>
-== 3D Structures of lactoferrin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Agglutinin
-**[[4r6r]], [[1ku8]] – jfAGG alpha+ beta-3 chains – jack fruit <br />
-**[[5d5g]] – AGG - tuber <br />
-**[[4uri]], [[1fny]] – RpAGG – ''Robinia pseudoacacia'' <br />
-**[[4g9m]] – RsAGG – ''Rhizoctonia solani''<br />
-**[[4gu8]] – BoAGG – ''Burkholderia oklahomensis''<br />
-**[[4fbo]] – AGG – ''Pseudomonas fluorescens'' <br />
-**[[2x2s]] – SsAGG – ''Sclerotinia sclerotiorum'' <br />
-**[[4fbr]] – MxAGG – ''Myxococcus xanthus'' <br />
-**[[3s5v]], [[3s60]] – OaAGG – ''Oscillatoria agardhi'' <br />
-**[[3lly]] – MpAGG alpha+ beta-2 chains – ''Maclura pomifera'' <br />
-**[[2ce6]] – HpAGG – ''Helix pomatia''<br />
-**[[1ouw]] – AGG – hedge bindweed<br />
-**[[1dlp]], [[1b2p]] – AGG – ''Scilla campanulata''<br />
-**[[1c3k]] – HtAGG – ''Helianthus tuberosus''<br />
-**[[1jly]] – AcAGG – ''Amaranthus caudatus''<br />
-* Agglutinin complex with polysaccharide
-**[[5j51]], [[5jm1]], [[4r6n]], [[4r6o]], [[4r6p]], [[4r6q]], [[4r6r]], [[4akc]], [[5j50]], [[5j4x]], [[5j4t]] – jfAGG alpha+ beta-3 chains + polysaccharide <br />
-**[[5jm1]] – jfAGG alpha+ beta-3 chains + trisaccharide <br />
-**[[1g9f]], [[2sba]], [[1sbd]], [[1sbe]], [[1sbf]] – soAGG + polysaccharide - soybean<br />
-**[[1jlx]] – AcAGG + polysaccharide <br />
-**[[4gk9]] – BoAGG + polysaccharide <br />
-**[[4fbv]] – MxAGG + polysaccharide <br />
-**[[3s5x]] – OaAGG + polysaccharide <br />
-**[[3llz]] – MpAGG + polysaccharide <br />
-**[[1c3m]], [[1c3n]] – HtAGG + polysaccharide <br />
-**[[1cr7]], [[1ciw]], [[2tep]], [[1bzw]], [[2pel]] – pAGG + polysaccharide - peanut<br />
-**[[2x2t]] – SsAGG + polysaccharide <br />
-**[[1jot]] – AGG + polysaccharide – osage orange<br />
-**[[3ef2]], [[2iho]] – MoAGG + polysaccharide – ''Marasmius oreades''<br />
-**[[3c9z]], [[3ca0]], [[3ca1]], [[3ca3]], [[3ca4]], [[3ca5]], [[3ca6]], [[3cah]] – AGG II + polysaccharide – ''Sambucus nigra''<br />
-**[[2zmk]], [[2zml]], [[2zmn]], [[2e51]], [[2e53]], [[2e7q]], [[2e7t]], [[1f9k]], [[1wbl]] – GbAGG + polysaccharide – Goa bean<br />
-**[[1jpc]], [[1niv]] – snAGG + polysaccharide – snowdrop<br />
-**[[2zr1]] – IlAGG alpha+ beta chains + polysaccharide – Indian licorice<br />
-**[[1ugy]], [[1uh1]] – jfAGG alpha+ beta-3 chains + polysaccharide <br />
-* Agglutinin complex with monosaccharide
-**[[4ak4]], [[4akb]], [[1jac]] – jfAGG alpha+ beta-3 chains + saccharide <br />
-**[[5kxb]] – wiAGG + GalNAc - wisteria <br />
-**[[5kxc]], [[5kxd]], [[5kxe]] – wiAGG + polysaccharide <br />
-**[[5d9z]] – AGG + mannose - taro <br />
-**[[3dzw]], [[1npl]] – AGG + mannose – daffodil <br />
-**[[4q56]] – AGG + saccharide – ''Helix aspersa''<br />
-**[[4g9n]] – RsAGG + saccharide <br />
-**[[2d3s]] – GbAGG + saccharide + antigen <br />
-**[[2dtw]], [[2dty]], [[2du0]], [[2du1]], [[1fay]], [[1wbf]] – GbAGG + saccharide <br />
-**[[2cgz]], [[2cgy]] – HpAGG + saccharide + antigen <br />
-**[[2ccv]] – HpAGG + saccharide <br />
-**[[1fnz]] – RpAGG + saccharide <br />
-**[[1qf3]] – pAGG + saccharide <br />
-**[[2cgz]] – AGG + saccharide – ''Bowringia milbraedii''<br />
-**[[1rzo]] – AGG + saccharide – ''Ricinus communis''<br />
-**[[1toq]], [[1tp8]] – AGG + saccharide – ''Artocarpus hirsuta''<br />
-**[[1msa]] – snAGG + saccharide <br />
-**[[2q3n]] – IlAGG alpha+ beta chains + saccharide <br />
-**[[1kj1]], [[1bwu]] – AGG I II chains + saccharide - garlic<br />
-**[[3lm1]] – MpAGG alpha+ beta-2 chains + saccharide <br />
-**[[1ws4]], [[1ws5]], [[1ugw]], [[1uh0]], [[1kuj]] – jfAGG alpha+ beta-3 chains + saccharide <br />
-**[[1ugx]], [[1m26]] – jfAGG alpha+ beta-3 chains + saccharide + antigen<br />
-*Agglutinin complex with other compounds
-**[[5d61]], [[5d62]], [[5d63]] – MoAGG + peptide inhibitor  <br />
-**[[5mu9]] – MoAGG + guanidine derivative  <br />
-**[[4d69]] – soAGG + peptide  <br />
-**[[1pxd]] – jfAGG alpha+ beta-3 chains + porphyrin derivative <br />
-*Agglutinin isolectin
-**[[7wga]], [[9wga]] – wgAGG 1 – wheat germ  <br />
-**[[4aml]] – wgAGG 1 + glycosylurethan  <br />
-**[[2x3t]], [[2cwg]] – wgAGG 1 + glycopeptide  <br />
-**[[2uvo]] – wgAGG 1 + NAG  <br />
-**[[1wgc]], [[2wgc]] – wgAGG 1+ polysaccharide  <br />
-**[[1en2]], [[1enm]] – gnAGG 1 + NAG – great nettle <br />
-**[[1wgt]] – wgAGG 3 <br />
-**[[2x52]] – wgAGG 3 + pyranose derivative <br />
-**[[1k7t]], [[1k7u]], [[1k7v]] – wgAGG 3 + polysaccharide  <br />
-**[[1iqb]], [[1eis]], [[1ehd]], [[1ehh]] – gnAGG 6  <br />
-**[[1ehh]] – gnAGG 6+ polysaccharide  <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]

Agglutinin

From Proteopedia

Current revision

Contents

Function

Disease

Structural highlights

3D Structures of agglutinin

References

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