We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Cytochrome P450

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:03, 6 January 2025) (edit) (undo)
 
(21 intermediate revisions not shown.)
Line 1: Line 1:
<StructureSection load='' size='350' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'>
<StructureSection load='' size='350' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'>
 +
__TOC__
 +
== Function ==
-
[[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref>.<br />
+
[[Cytochrome P450]] (P450) or '''cytochrome P450 monooxygenase''' catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref> P450 CYP121 is called '''mycocyclosin synthase'''.
-
* '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.<br />
+
* '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor<ref>PMID:10698731</ref>.<br />
-
* '''P450nor''' is a Nitric Oxide Reductase P450.<br />
+
* '''P450nor''' is a Nitric Oxide Reductase P450<ref>PMID:15598501</ref>.<br />
-
* '''P450epoK''' converts epothilone D to epothilone B.<br />
+
* '''P450epoK''' converts epothilone D to epothilone B<ref>PMID:12933799</ref>.<br />
-
* '''P450cin''' monooxygenates 1,8-cineole which is similar to camphor.<br />
+
* '''P450cin''' monooxygenates 1,8-cineole which is similar to camphor<ref>PMID:26002741</ref>.<br />
* '''Bifunctional P450/NADPH P450 reductase''' (P450 BM3) is a fatty acid monooxygenase.<br />
* '''Bifunctional P450/NADPH P450 reductase''' (P450 BM3) is a fatty acid monooxygenase.<br />
* '''P450 3A4''' see [[CYP3A4]].<br />
* '''P450 3A4''' see [[CYP3A4]].<br />
* '''P450 19 family''' see [[Aromatase]].<br />
* '''P450 19 family''' see [[Aromatase]].<br />
-
Additional details in [[Drug Metabolism by CYP450 Enzymes]].<br />
+
* '''P450 17A1''' see [[Abiraterone acetate|Human steroidogenic cytochrome P450 17A1 with inhibitor abiraterone]]
-
[[Noxafil]] is an antifungal drug which binds to CYP51.
+
See also [[Hemeproteins]].
 +
 
 +
Additional details on cytochrome P450 interactions with drugs see
 +
*[[Drug Metabolism by CYP450 Enzymes]]<br />
 +
*[[Montelukast]] - anti rhinitis
 +
*[[Noxafil]] - antifungal drug which binds to CYP51.
 +
*[[Antifungal drugs]] - antifungal drugs which binds to CYP51.
 +
*[[Cobicistat]] - anti HIV/AIDS drug which binds to CYP3A4.
 +
*[[Cytochrome P450 inhibitors]]
== Structural highlights ==
== Structural highlights ==
-
The <scene name='43/430105/Cv/4'>heme moiety is stabilized by several side chains</scene>. The <scene name='43/430105/Cv/5'>heme iron is pentacoordinated with Cys as one ligand</scene>.<ref>PMID:12861225</ref>
+
The <scene name='43/430105/Cv/6'>heme moiety is stabilized by several side chains</scene>. The <scene name='43/430105/Cv/7'>heme iron is pentacoordinated with Cys as one ligand</scene>.<ref>PMID:12861225</ref>
-
</StructureSection>
+
 
== 3D Structures of Cytochrome P450 ==
== 3D Structures of Cytochrome P450 ==
 +
[[Cytochrome P450 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
* human P450 1 family
+
-
+
-
**[[2hi4]] – hP4501A2+naphthoflavone - human<br />
+
-
**[[4i8v]] - hP4501A1 +naphthoflavone<br />
+
-
**[[3pm0]] - hP4501B1+naphthoflavone<br />
+
-
 
+
-
* human P450 2 family
+
-
+
-
**[[2pg5]], [[2pg6]], [[2pg7]] – hP4502A6 (mutant)<br />
+
-
**[[3ebs]] – hP4502A6 (mutant)+phenacetin<br />
+
-
**[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
+
-
**[[1z10]] - hP4502A6 catalytic domain+coumarin<br />
+
-
**[[4ejj]] - hP4502A6 + nicotine<br />
+
-
**[[3t3q]], [[3t3r]] - hP4502A6 (mutant) + pilocarpine<br />
+
-
**[[2z10]] – hP4502A6+coumarin<br />
+
-
**[[1z11]] - hP4502A6+methoxalen<br />
+
-
**[[4rui]] – hP450 2A6 + volatile hydrocarbon<br />
+
-
**[[3t3s]] - hP4502A13 + pilocarpine<br />
+
-
**[[4ejg]] - hP4502A13 + nicotine<br />
+
-
**[[4ejh]], [[4eji]] - hP4502A13 + pyridine derivative<BR />
+
-
**[[2p85]] – hP4502A13 (mutant)+indole<br />
+
-
**[[3ibd]] – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole<br />
+
-
**[[3ua5]] – hP4502B6 (mutant) + amlodipine<br />
+
-
**[[4i91]], [[4zv8]] - hP4502B6 (mutant) + pinine<br />
+
-
**[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2B6 (mutant) + inhibitor<br />
+
-
**[[4rql]], [[4rrt]] – hP450 2B6 (mutant) + volatile hydrocarbon<br />
+
-
**[[5e58]] – dwP450 2B35 + inhibitor – desert woodrat<br />
+
-
**[[5e0e]] – dwP450 2B37 + inhibitor <br />
+
-
**[[2nnh]] – hP4502C8+retinoic acid<br />
+
-
**[[2nni]] - hP4502C8+montelukast<br />
+
-
**[[2nnj]] - hP4502C8+felodipine<br />
+
-
**[[1pq2]] - hP4502C8<br />
+
-
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
+
-
**[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
+
-
**[[5a5i]], [[5a5j]] - hP4502C9 + inhibitor<br />
+
-
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br />
+
-
**[[4gqs]] - hP4502C19 catalytic domain<br />
+
-
**[[2f9q]], [[3qm4]] – hP4502D6<br />
+
-
**[[3tbg]], [[4wnw]] – hP4502D6 + thioridazine<br />
+
-
**[[3tda]] – hP4502D6 + prinomastat<br />
+
-
**[[4wnt]] - hP4502D6 + ajmalicine<br />
+
-
**[[4wnu]], [[4wnv]] - hP4502D6 + quinine derivative<br />
+
-
**[[5tft]], [[5tfu]], [[4xry]], [[4xrz]] - hP4502D6 + Bace1 inhibitor<br />
+
-
**[[3gph]], [[3koh]], [[3lc4]] – hP4502E1 fragment +imidazole derivative<br />
+
-
**[[3e6i]] – hP4502E1 fragment+indazole<br />
+
-
**[[3e4e]] – hP4502E1 fragment+methylpyrazole<br />
+
-
**[[3t3z]] - hP4502E1 + pilocarpine<br />
+
-
**[[3czh]], [[3dl9]], [[3c6g]] – hP4502R1+vitamin D<br />
+
-
 
+
-
* human P450 3 family
+
-
 
+
-
**[[2v0m]] – hP4503A4+ anti-fungal drug<br />
+
-
**[[2j0d]] - hP4503A4+ antibiotic<br />
+
-
**[[3nxu]], [[3tjs]] - hP4503A4+ anti-HIV drug<br />
+
-
**[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]] - hP4503A4 (mutant) + anti-HIV drug<br />
+
-
**[[3ua1]] - hP4503A4 + ergocryptine<br />
+
-
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
+
-
**[[4i3q]] - hP4503A4 (mutant) <br />
+
-
**[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]] - hP4503A4 + inhibitor <br />
+
-
**[[5te8]] - hP4503A4 + sedation drug <br />
+
-
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
+
-
 
+
-
* human P450 7 family
+
-
 
+
-
**[[3dax]] – hP4507A1<br />
+
-
**[[3sn5]] - hP4507A1 + cholest-4-en-3-one
+
-
 
+
-
*human P450 11 family
+
-
 
+
-
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
+
-
**[[4fdh]] - hP450 CYP11B2 + fadrozole<br />
+
-
**[[4zgx]] - hP450 CYP11B2 + inhibitor<br />
+
-
 
+
-
* human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase)
+
-
 
+
-
**[[5uys]], [[3ruk]] - hP450 C17 + abiraterone derivative<br />
+
-
**[[4nkv]] - hP450 C17 (mutant) + abiraterone derivative<br />
+
-
**[[5irq]] - hP450 C17 + orteronel<br />
+
-
**[[5irv]] - hP450 C17 + inhibitor<br />
+
-
**[[4nkw]], [[4nkz]] - hP450 C17 (mutant) + pregnenolone derivative<br />
+
-
**[[4nkx]], [[4nky]] - hP450 C17 (mutant) + progesterone derivative<br />
+
-
**[[3swz]] - hP450 C17 + drug<br />
+
-
 
+
-
* human P450 19 family (aromatase)
+
-
 
+
-
**[[3eqm]], [[3s79]], [[4kq8]] - hP45019A1+androstenedione<br />
+
-
**[[3s7s]] - hP45019A1 + exemestane<br />
+
-
**[[4gl5]], [[4gl7]] - hP45019A1 + inhibitor
+
-
 
+
-
* human P450 46 family
+
-
 
+
-
**[[2q9f]] – hP45046A1+cholesterol<br />
+
-
**[[2q9d]], [[2q9g]] - hP45046A1<br />
+
-
**[[2vn0]] – hP450105A1+troglitazone<br />
+
-
**[[2zby]] - hP450105A1 (mutant)
+
-
 
+
-
* P450 from ''Mycobacterium tuberculosis'' or sterol 14-α demethylase
+
-
 
+
-
**[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br />
+
-
**[[2ci0]], [[2cib]], [[1u13]] - MtP450 CYP51 (mutant)<br />
+
-
**[[1x8v]] - MtP450 CYP51 (mutant)+estriol<br />
+
-
**[[1ea1]] - MtP450 CYP51 (mutant)+ fluconazole<br />
+
-
**[[1e9x]] - MtP450 CYP51 (mutant)+ phenylimidazole<br />
+
-
**[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450 CYP121 (mutant)<br />
+
-
**[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450 CYP121<br />
+
-
**[[2ij7]] - MtP450 CYP121+fluconazole<br />
+
-
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]] - MtP450 CYP121+pyrazole derivative<br />
+
-
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450 CYP121 + piperazine derivative<br />
+
-
**[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]], [[5ibg]], [[5ibh]], [[5ibi]], [[5ibj]], [[5ibd]], [[5ibe]], [[5ibf]], [[5edt]] - MtP450 CYP121 + inhibitor<br />
+
-
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br />
+
-
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
+
-
**[[3iw2]] - MtP450 CYP125+econazole<br />
+
-
**[[2uvn]] - MtP450 CYP130+econazole<br />
+
-
**[[2wgy]] – MtP450 CYP130 (mutant)<br />
+
-
**[[2w09]], [[2w0b]], [[2w0a]] - MtP450 CYP130 (mutant)+pyridine inhibitor<br />
+
-
**[[2uuq]] – MtP450 CYP130<br />
+
-
**[[5hdi]] - MtP450 CYP144A1<br />
+
-
 
+
-
* P450cam
+
-
 
+
-
**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]],[[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]] – PpP450cam(mutant) – ''Pseudomona putida''<br />
+
-
**[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]] - PpP450cam<br />
+
-
**[[2qbo]] - PpP450cam (mutant)+cyanide<br />
+
-
**[[1qmq]] - PpP450cam (mutant)+Ru substrate<br />
+
-
**[[2h7q]] - PpP450cam+imidazole<br />
+
-
**[[1cp4]] - PpP450cam+benzene<br />
+
-
**[[1akd]], [[1iwi]], [[1noo]], [[7cpp]], [[8cpp]], [[2zwt]], [[2zwu]], [[5ik1]] - PpP450cam+1S-camphor derivative<br />
+
-
**[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br />
+
-
**[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br />
+
-
**[[4l4d]], [[4l4e]], [[4l4f]], [[4l4g]] - PpP450cam (mutant)+ camphor + CN<br />
+
-
**[[4kky]] - PpP450cam (mutant)+ camphor + pyrene derivative<br />
+
-
**[[2l8m]] – PpP450cam+camphor+CO<br />
+
-
**[[4g3r]] – PpP450cam+camphor+NO<br />
+
-
**[[2fe6]], [[2fer]], [[2feu]] - PpP450cam+Mn protoporphyrin IX<br />
+
-
**[[1uyu]] - PpP450cam+ Xe<br />
+
-
**[[1o76]] - PpP450cam+cyanide<br />
+
-
**[[4cpp]] - PpP450cam+adamantine<br />
+
-
**[[5cpp]] - PpP450cam+adamantanone<br />
+
-
**[[6cpp]] - PpP450cam+camphene<br />
+
-
**[[1p2y]], [[1p7r]] - PpP450cam+nicotine<br />
+
-
**[[1re9]], [[1rf9]] - PpP450cam +fluorescent probe<br />
+
-
**[[2z97]], [[2zaw]], [[2zax]] - PpP450cam+methyl depropionated hemin<br />
+
-
**[[3cpp]], [[2lqd]] - PpP450cam+CO<br />
+
-
**[[1pha]], [[1phb]], [[1phd]], [[1phe]], [[1phf]], [[1phg]] - PpP450cam+imidazole derivative<br />
+
-
**[[1gek]], [[1gem]] - PpP450cam+N-butyl-isocyanide<br />
+
-
**[[1lwl]] - PpP450cam+fluorescent probe<br />
+
-
**[[2h7r]] - PpP450cam (mutant)+imidazole<br />
+
-
**[[1k2o]] - PpP450cam (mutant)+pyridine derivative<br />
+
-
**[[1gjm]] - PpP450cam (mutant)+sulphydryl reagent<br />
+
-
**[[2a1m]], [[2a1n]], [[2a10]] - PpP450cam (mutant)+ferrous dioxygen<br />
+
-
**[[1t85]], [[1t86]], [[1t87]], [[1t88]] - PpP450cam (mutant)+ferrous CO<br />
+
-
**[[1j51]] - PpP450cam (mutant)+trichlorobenzene<br />
+
-
**[[1mpw]] - PpP450cam (mutant)+trimethylbicycloheptene<br />
+
-
**[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]] - PpP450cam (mutant)+substrate analog<br />
+
-
**[[4jws]], [[4jwu]] - PpP450cam (mutant)+ putidaredoxin<br />
+
-
**[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br />
+
-
**[[2m56]] - PpP450cam + putidaredoxin + camphor <br />
+
-
**[[3w9c]], [[5gxg]] - PpP450cam (mutant)+ putidaredoxin <br />
+
-
**[[3oft]], [[4c9m]], [[3lxh]], [[3lxi]], [[3ofu]] – NaP450 – ''Novosphignobium aromaticivorans''<br />
+
-
**[[4c9p]] - NaP450cam (mutant) + camphor <br />
+
-
**[[4c9k]] - NaP450cam + camphor + hydroxycamphor<br />
+
-
**[[4c9n]] - NaP450cam (mutant) + camphor + hydroxycamphor<br />
+
-
**[[4c9l]] - NaP450cam + camphor + CN<br />
+
-
**[[4c9o]] - NaP450cam (mutant) + camphor + CN<br />
+
-
 
+
-
* P450nor
+
-
 
+
-
**[[1cl6]], [[1rom]] – FoP450nor - ''Fusarium oxysporum''<br />
+
-
**[[2rom]] - FoP450nor+CO<br />
+
-
**[[1cmj]], [[1cmn]], [[1ehg]] - FoP450nor (mutant)<br />
+
-
**[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br />
+
-
**[[1jfb]], [[1jfc]], [[1ged]], [[1ehe]] - FoP450nor<br />
+
-
**[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br />
+
-
**[[1ulw]] - FoP450nor (mutant)
+
-
 
+
-
*P450epoK
+
-
 
+
-
**[[1pkf]] – ScP450epoK+epothilone D – ''Sorangium cellulosum''
+
-
 
+
-
*P450cin
+
-
 
+
-
**[[3bdz]], [[3be0]], [[4fyz]], [[4fb2]] – CbP450cin – ''Citrobacter braakii''<br />
+
-
**[[4lht]], [[4l77]] - CbP450cin (mutant)<br />
+
-
**[[4fmx]] – CbP450cin + cineole<br />
+
-
**[[4l6g]] – CbP450cin (mutant) + cineole<br />
+
-
 
+
-
* rabbit P450
+
-
 
+
-
**[[2bdm]] – rP450 CYP2B4 – rabbit<br />
+
-
**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]], [[5iut]], [[5iuz]], [[5em4]] - rP450 CYP2B4 (mutant)<br />
+
-
**[[1suo]],[[3g5n]], [[3g93]], [[2q6n]], [[3tk3]] - rP450 CYP2B4 (mutant)+imidazole derivative<br />
+
-
**[[4mgj]] - rP450 CYP2B4 (mutant)+ thiol derivative<br />
+
-
**[[3kw4]], [[3me6]], [[3tmz]], [[4h1n]] - rP450 CYP2B4 (mutant)+anti-platelet drug<br />
+
-
**[[4jlt]] - rP450 CYP CYP2B4 (mutant) + anti-depressant drug<br />
+
-
**[[3uas]] - rP450 CYP CYP2B4 (mutant)+ inactivator<br />
+
-
**[[5t6q]] - rP450 CYP4B1 + octane<br />
+
-
**[[1dt6]] - rP450 CYP2C5 (mutant)<br />
+
-
**[[1nr6]] – rP450 CYP2C5+diclofenac<br />
+
-
**[[1n6b]] - rP450 CYP2C5+sulfaphenazole
+
-
 
+
-
*P450 BM3
+
-
 
+
-
**[[3cbd]], [[2bmh]] – BmP450 heme domain – ''Bacillus megaterium''<br />
+
-
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]] - BmP450 heme domain (mutant)<br />
+
-
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br />
+
-
**[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br />
+
-
**[[1jpz]], [[1zo9]], [[1zoa]], [[4kpa]] - BmP450 heme domain + palmitate derivative<br />
+
-
**[[1smj]], [[5jq2]] - BmP450 heme domain (mutant) + palmitate derivative<br />
+
-
**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br />
+
-
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br />
+
-
**[[4kew]], [[4key]], [[4o4p]] - BmP450 heme domain (mutant) + omeprazole<br />
+
-
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br />
+
-
**[[2ij2]], [[2hpd]] - BmP450102 heme domain<br />
+
-
**[[4dqk]] - BmP450 FAD domain + FAD<br />
+
-
**[[4dql]] - BmP450 FAD domain + NADP + FAD<br />
+
-
**[[3wsp]] - BmP450 + decoy molecule<br />
+
-
**[[2uwh]] - BmP450102+palmitic acid<br />
+
-
**[[3ben]] - BmP450 heme domain + inhibitor<br />
+
-
**[[2j1m]] - BmP450102 heme domain +DMSO<br />
+
-
**[[1bvy]], [[1bu7]] – BmP450102A1 FMN domain<br />
+
-
**[[1fag]] – BmP450102A1+ palmitic acid<br />
+
-
**[[4yt3]] - BmP450 CYP106A2 <br />
+
-
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br />
+
-
**[[5l90]] - BmP450 CYP109E1 <br />
+
-
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br />
+
-
**[[5l94]] - BmP450 CYP109E1 + testosterone<br />
+
-
 
+
-
* Other CYPs
+
-
 
+
-
**[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
+
-
**[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
+
-
**[[4oqs]] - AoP450 CYP105AS1<br />
+
-
**[[5kyo]] - P450 CYP101J2 – ''Sphingobium yanoikuyae''<br />
+
-
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
+
-
**[[5ex6]] - P450 – ''Streptomyces toyocaensis''<br />
+
-
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
+
-
**[[4wpz]] - SaP450 CYP107W1 – ''Streptomyces avermitilis''<br />
+
-
**[[3abb]] – SaP450 CYP105D6<br />
+
-
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
+
-
**[[1q5e]] - ScP450EPOK - ''Sorangium cellulosum''<br />
+
-
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
+
-
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
+
-
**[[1cpt]] – P450 TERP – ''Pseudomonas sp.''<br />
+
-
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
+
-
**[[4r20]], [[4r21]] - P45017A2 – zebra fish<br />
+
-
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
+
-
**[[2bvj]] - SvP450107L1<br />
+
-
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br />
+
-
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
+
-
**[[4rm4]] - BsP450 CYP109B1<br />
+
-
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
+
-
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
+
-
**[[2z3t]] - StrP450 CYP245A1 - ''Streptomyces sp.''<br />
+
-
**[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
+
-
**[[5liv]] - ScP450 CYP260A1 <br />
+
-
**[[5hiw]] - ScP450 CYP260B1 <br />
+
-
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
+
-
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
+
-
**[[3r9b]] – MsP450 CYP16A2 <br />
+
-
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
+
-
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
+
-
**[[1gwi]] - ScP450 CYP154C1<br />
+
-
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
+
-
**[[1n97]] – TtP450 CYP175A1<br />
+
-
**[[3nv5]], [[3nv6]], [[4dxy]] - NaP450 CYP101D2<br />
+
-
**[[3tkt]] – NaP450 CYP108D1<br />
+
-
**[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br />
+
-
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
+
-
**[[3a4z]] - PaP450 VDH (mutant)<br />
+
-
**[[3qi8]] – P450 – synthetic<br />
+
-
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
+
-
**[[3o1a]] – P450 CYP165D3 – ''Actinoplanes teichomyceticus''<br />
+
-
**[[4e2p]] - P450 – ''Streptococcus himastatinicus''<br />
+
-
 
+
-
*Other CYPs complexes
+
-
 
+
-
**[[1q5d]] – ScP450EPOK+epothilone <br />
+
-
**[[1f4t]] - SsP450 CYP119+ phenylimidazole<br />
+
-
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
+
-
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br />
+
-
**[[3aba]] – SaP450 CYP105P1+filipin I <br />
+
-
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
+
-
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br />
+
-
**[[2vzm]] – SvP450107L1 (mutant)+narbomycin<br />
+
-
**[[2c7x]] - SvP450107L1+narbomycin<br />
+
-
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450107L1+YC-17<br />
+
-
**[[2zqx]] - BsP450152A1+heptanoic acid<br />
+
-
**[[1izo]] – BsP450 BS beta+ palmitoleic acid<br />
+
-
**[[1jin]], [[1jip]] - SeP450107A1+ ketoconazole <br />
+
-
**[[1jio]], [[1oxa]] - SeP450107A1+6DEB<br />
+
-
**[[1eup]] – SeP450107A1+androstendione<br />
+
-
**[[1egy]] - SeP450107A1+aminophenanthrene<br />
+
-
**[[2jjp]] - SeP450 CYP113A1 (mutant)+ketoconazole<br />
+
-
**[[2xfh]] - SeP450 CYP113A1 (mutant)+clotrimazole<br />
+
-
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
+
-
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
+
-
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
+
-
**[[5fsa]] – P450 CYP51 (mutant) + posaconazole - ''Candida albicans''<br />
+
-
**[[2rch]], [[3dsi]] – AtP45074A+13(S)-HOD <br />
+
-
**[[3dsj]] - AtP45074A (mutant)+13(S)-HOD<br />
+
-
**[[2rcl]] - AtP45074A+vernolic acid<br />
+
-
**[[3dsk]] - AtP45074A (mutant)+ vernolic acid<br />
+
-
**[[3r9c]] – MsP450 CYP16A2 + econazole<br />
+
-
**[[2rfc]] – PtP450+phenylimidazole<br />01D2<br />
+
-
**[[3tkt]] – NaP450 CYP108D1<br />
+
-
**[[3awm]] – SpP450-α + palmitic acid <br />
+
-
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
+
-
**[[4do1]], [[4egm]] – RpP450 CYP199A4 + benzoate derivative<br />
+
-
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
+
-
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
+
-
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
+
-
**[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br />
+
-
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
+
-
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
+
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry 1og5)

Drag the structure with the mouse to rotate

References

  1. ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
  2. ↑ Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG. The catalytic pathway of cytochrome p450cam at atomic resolution. Science. 2000 Mar 3;287(5458):1615-22. PMID:10698731
  3. ↑ Daiber A, Shoun H, Ullrich V. Nitric oxide reductase (P450nor) from Fusarium oxysporum. J Inorg Biochem. 2005 Jan;99(1):185-93. PMID:15598501 doi:10.1016/j.jinorgbio.2004.09.018
  4. ↑ Nagano S, Li H, Shimizu H, Nishida C, Ogura H, Ortiz de Montellano PR, Poulos TL. Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. J Biol Chem. 2003 Nov 7;278(45):44886-93. Epub 2003 Aug 21. PMID:12933799 doi:http://dx.doi.org/10.1074/jbc.M308115200
  5. ↑ Stok JE, Slessor KE, Farlow AJ, Hawkes DB, De Voss JJ. Cytochrome P450cin (CYP176A1). Adv Exp Med Biol. 2015;851:319-39. PMID:26002741 doi:10.1007/978-3-319-16009-2_12
  6. ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Cytochrome_P450"
Personal tools