6axa

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'''Unreleased structure'''
 
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The entry 6axa is ON HOLD until Paper Publication
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==Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with (3S)-5-fluoro-3-hydroxy-1,3-dihydroindol-2-one==
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<StructureSection load='6axa' size='340' side='right'caption='[[6axa]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6axa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AXA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=D4Y:(3~{S})-5-fluoranyl-3-oxidanyl-1,3-dihydroindol-2-one'>D4Y</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6axa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6axa OCA], [https://pdbe.org/6axa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6axa RCSB], [https://www.ebi.ac.uk/pdbsum/6axa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6axa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0U3AGT1_SCHMA A0A0U3AGT1_SCHMA] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.[PIRNR:PIRNR000477]
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Authors: Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
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==See Also==
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*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
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Description: Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with (3S)-5-fluoro-3-hydroxy-1,3-dihydroindol-2-one
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Pearce, N.M]]
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[[Category: Large Structures]]
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[[Category: Collins, P]]
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[[Category: Schistosoma mansoni]]
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[[Category: Faheem, M]]
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[[Category: Barbosa JARG]]
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[[Category: Delft, F.V]]
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[[Category: Bird L]]
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[[Category: Pereira, H.M]]
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[[Category: Collins P]]
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[[Category: Neto, J.B]]
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[[Category: Delft FV]]
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[[Category: Barbosa, J.A.R.G]]
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[[Category: Faheem M]]
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[[Category: Valadares, N.F]]
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[[Category: Neto JB]]
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[[Category: Bird, L]]
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[[Category: Pearce NM]]
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[[Category: Pereira HM]]
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[[Category: Valadares NF]]

Current revision

Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with (3S)-5-fluoro-3-hydroxy-1,3-dihydroindol-2-one

PDB ID 6axa

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