2fl9

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[[Image:2fl9.gif|left|200px]]
 
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{{Structure
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==Evolution of bacteriophage tails: Structure of T4 gene product 10==
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|PDB= 2fl9 |SIZE=350|CAPTION= <scene name='initialview01'>2fl9</scene>
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<SX load='2fl9' size='340' side='right' viewer='molstar' caption='[[2fl9]], [[Resolution|resolution]] 17.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2fl9]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FL9 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 17&#8491;</td></tr>
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|GENE= 10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fl9 OCA], [https://pdbe.org/2fl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fl9 RCSB], [https://www.ebi.ac.uk/pdbsum/2fl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fl9 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1fl8|1FL8]], [[2fkk|2FKK]], [[1s2e|1S2E]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fl9 OCA], [http://www.ebi.ac.uk/pdbsum/2fl9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fl9 RCSB]</span>
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[https://www.uniprot.org/uniprot/BP10_BPT4 BP10_BPT4] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:16554069). During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.<ref>PMID:16554069</ref> <ref>PMID:21129200</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Evolution of bacteriophage tails: Structure of T4 gene product 10'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2fl9_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The success of tailed bacteriophages to infect cells far exceeds that of most other viruses on account of their specialized tail and associated baseplate structures. The baseplate protein gene product (gp) 10 of bacteriophage T4, whose structure was determined to 1.2 A resolution, was fitted into the cryo-electron microscopy structures of the pre and post-infection conformations of the virus. gp10 functions as a molecular lever that rotates and extends the hinged short tail fibers to facilitate cell attachment. The central folding motif of the gp10 trimer is similar to that of the baseplate protein gp11 and to the receptor-binding domain of the short tail fiber, gp12. The three proteins comprise the periphery of the baseplate and interact with each other. The structural and functional similarities of gp10, gp11, and gp12 and their sequential order in the T4 genome suggest that they evolved separately, subsequent to gene triplication from a common ancestor. Such events are usual in the evolution of complex organelles from a common primordial molecule.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fl9 ConSurf].
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2FL9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL9 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Evolution of bacteriophage tails: Structure of T4 gene product 10., Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG, J Mol Biol. 2006 May 5;358(3):912-21. Epub 2006 Mar 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16554069 16554069]
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__TOC__
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[[Category: Enterobacteria phage t4]]
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</SX>
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[[Category: Single protein]]
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[[Category: Escherichia virus T4]]
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[[Category: Leiman, P G.]]
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[[Category: Large Structures]]
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[[Category: Mesyanzhinov, V V.]]
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[[Category: Leiman PG]]
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[[Category: Rossmann, M G.]]
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[[Category: Mesyanzhinov VV]]
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[[Category: Shneider, M M.]]
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[[Category: Rossmann MG]]
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[[Category: bacteriophage t4]]
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[[Category: Shneider MM]]
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[[Category: baseplate]]
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[[Category: evolution]]
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[[Category: gp10]]
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[[Category: structural comparison]]
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[[Category: tail]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:04:19 2008''
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Current revision

Evolution of bacteriophage tails: Structure of T4 gene product 10

2fl9, resolution 17.00Å

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