This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2fmu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:54, 20 September 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2fmu.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of a tat-interacting protein homologue (htatip2, aw111545, cc3, tip30) from mus musculus at 2.30 A resolution==
-
|PDB= 2fmu |SIZE=350|CAPTION= <scene name='initialview01'>2fmu</scene>, resolution 2.300&Aring;
+
<StructureSection load='2fmu' size='340' side='right'caption='[[2fmu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
+
<table><tr><td colspan='2'>[[2fmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FMU FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
|GENE= 16924205 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3320 COG3320], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01118 Semialdhyde_dh]</span>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmu OCA], [https://pdbe.org/2fmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fmu RCSB], [https://www.ebi.ac.uk/pdbsum/2fmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fmu ProSAT], [https://www.topsan.org/Proteins/JCSG/2fmu TOPSAN]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmu OCA], [http://www.ebi.ac.uk/pdbsum/2fmu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fmu RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/HTAI2_MOUSE HTAI2_MOUSE] Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import.<ref>PMID:14695192</ref>
-
 
+
== Evolutionary Conservation ==
-
'''Crystal structure of Tat-interacting protein 30 kDa (HIV-1 tat interactive protein 2, 30 kDa homolog) (Human) (16924205) from Mus musculus at 2.30 A resolution'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/2fmu_consurf.spt"</scriptWhenChecked>
-
2FMU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMU OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fmu ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
 
-
[[Category: JCSG, Joint Center for Structural Genomics.]]
 
-
[[Category: 16924205]]
 
-
[[Category: 30 kda homolog) (human)]]
 
-
[[Category: jcsg]]
 
-
[[Category: joint center for structural genomic]]
 
-
[[Category: protein structure initiative]]
 
-
[[Category: psi]]
 
-
[[Category: structural genomic]]
 
-
[[Category: tat-interacting protein 30 kda (hiv-1 tat interactive protein 2]]
 
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:04:59 2008''
 

Current revision

Crystal structure of a tat-interacting protein homologue (htatip2, aw111545, cc3, tip30) from mus musculus at 2.30 A resolution

PDB ID 2fmu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fmu"
Personal tools