1tfr

<StructureSection load='1tfr' size='340' side='right' caption='[[1tfr]], [[Resolution|resolution]] 2.06&Aring;' scene=''>

<table><tr><td colspan='2'>[[1tfr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TFR FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfr OCA], [http://pdbe.org/1tfr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tfr RCSB], [http://www.ebi.ac.uk/pdbsum/1tfr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfr ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/RNH_BPT4 RNH_BPT4]] 5' to 3' exonuclease that removes the pentamer RNA primers from DNA chains initiated by the T4 primase-helicase.

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== Publication Abstract from PubMed ==

Bacteriophage T4 RNase H is a 5' to 3' exonuclease that removes RNA primers from the lagging strand of the DNA replication fork and is a member of the RAD2 family of eukaryotic and prokaryotic replication and repair nucleases. The crystal structure of the full-length native form of T4 RNase H has been solved at 2.06 angstroms resolution in the presence of Mg2+ but in the absence of nucleic acids. The most conserved residues are clustered together in a large cleft with two Mg2+ in the proposed active site. This structure suggests the way in which the widely separated conserved regions in the larger nucleotide excision repair proteins, such as human XPG, could assemble into a structure like that of the smaller replication nucleases.

Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins.,Mueser TC, Nossal NG, Hyde CC Cell. 1996 Jun 28;85(7):1101-12. PMID:8674116<ref>PMID:8674116</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1tfr" style="background-color:#fffaf0;"></div>

*[[Ribonuclease|Ribonuclease]]

[[Category: Bpt4]]

[[Category: Ribonuclease H]]

[[Category: Hyde, C C]]

[[Category: Mueser, T C]]

[[Category: Nossal, N G]]

[[Category: Rna:rna]]