1t61

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==crystal structure of collagen IV NC1 domain from placenta basement membrane==
==crystal structure of collagen IV NC1 domain from placenta basement membrane==
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<StructureSection load='1t61' size='340' side='right' caption='[[1t61]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='1t61' size='340' side='right'caption='[[1t61]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1t61]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T61 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1t61]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T61 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m3d|1m3d]], [[1li1|1li1]], [[1t60|1t60]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t61 OCA], [http://pdbe.org/1t61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t61 RCSB], [http://www.ebi.ac.uk/pdbsum/1t61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t61 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t61 OCA], [https://pdbe.org/1t61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t61 RCSB], [https://www.ebi.ac.uk/pdbsum/1t61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t61 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CO4A1_BOVIN CO4A1_BOVIN] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.[UniProtKB:P02463] Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.[UniProtKB:P02462]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t61_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t61_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Collagen|Collagen]]
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*[[Collagen 3D structures|Collagen 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Bondar, O]]
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[[Category: Large Structures]]
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[[Category: Friedman, D B]]
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[[Category: Bondar O]]
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[[Category: Hudson, B G]]
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[[Category: Friedman DB]]
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[[Category: Shanmugasundararaj, S]]
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[[Category: Hudson BG]]
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[[Category: Sundaramoorthy, M]]
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[[Category: Shanmugasundararaj S]]
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[[Category: Vanacore, R M]]
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[[Category: Sundaramoorthy M]]
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[[Category: Basement membrane]]
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[[Category: Vanacore RM]]
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[[Category: Nc1 domain]]
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[[Category: Structural protein]]
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[[Category: Type iv collagen]]
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Current revision

crystal structure of collagen IV NC1 domain from placenta basement membrane

PDB ID 1t61

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